For hundreds of years of death in most cultures was accepted as an act of God as something definite to which man couldn't nor had permission to affect. The founders of the modern concept of cardiopulmonary resucitacije consisting of the chest compression and lung ventilation using positive pressure thereby to artificially maintain blood flow and oxygen supply to vital organs are Peter Safar and Jemes Elam. Successful resuscitation is possible only with the proper functioning of all links in the chain of survival, which consists of: early activation of the emergency services, early application of basic life support (BLS), early defibrillation, early advanced life support procedures (ALS) and integrated postresuscitation care. Trained rescuer should as quickly as possible approach the victim and check its reactivity and if the victim is unresponsive, without palpable pulse and not breathing normally inform emergency services. High-quality cardiopulmonary resuscitation remains a key part of the success of the procedure. The guidelines from 2015. still require compression depth 5-6 cm frequency 100-120 / min. Emergency medicine dispatcher plays an important role in the early diagnosis of cardiac arrest and telephone guided resucitation and should provide information on nearby location of automatic external defibrillators, which should be placed on as many public places. Procedures of an advanced life support include CPR, defibrillation, recognition and treatment of possible reversible causes of cardiac arrest (4H and 4T), the establishment of a secure airway and adequate vascular access following a given algorithm. All citizens would at least should be capable and trained in standard CPR that includes chest compression and ventilation with 30:2 ratio. New guidelines and recommendations are issued by the ERC Resuscitation every five years based on new research and scientific knowledge. The last guidelines were issued in October 2015.