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master's thesis
Povezanost gastrointestinalnih krvarenja i primjene antikoagulantne terapije
2021. urn:nbn:hr:184:756753
Goričanec, Karla
University of Rijeka
Faculty of Medicine
Department of Internal Medicine

Cite this document

Goričanec, K. (2021). Povezanost gastrointestinalnih krvarenja i primjene antikoagulantne terapije (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:756753

Goričanec, Karla. "Povezanost gastrointestinalnih krvarenja i primjene antikoagulantne terapije." Master's thesis, University of Rijeka, Faculty of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:184:756753

Goričanec, Karla. "Povezanost gastrointestinalnih krvarenja i primjene antikoagulantne terapije." Master's thesis, University of Rijeka, Faculty of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:184:756753

Goričanec, K. (2021). 'Povezanost gastrointestinalnih krvarenja i primjene antikoagulantne terapije', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 26 December 2024, https://urn.nsk.hr/urn:nbn:hr:184:756753

Goričanec K. Povezanost gastrointestinalnih krvarenja i primjene antikoagulantne terapije [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2021 [cited 2024 December 26] Available at: https://urn.nsk.hr/urn:nbn:hr:184:756753

K. Goričanec, "Povezanost gastrointestinalnih krvarenja i primjene antikoagulantne terapije", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:184:756753

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Metadata
TitlePovezanost gastrointestinalnih krvarenja i primjene antikoagulantne terapije
Title (english)The Association between Gastrointestinal Bleeding and Anticoagulation Treatment
AuthorKarla Goričanec
MentorGoran Poropat (mentor)
Committee memberSandra Milić (predsjednik povjerenstva)
Committee memberTamara Turk Wensveen (član povjerenstva)
Committee memberVanja Licul (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Rijeka
Defense date and country2021-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Cilj: Cilj ovog diplomskog rada bio je ispitati utjecaj primjene antikoagulantnih lijekova na kliničke osobitosti gastrointestinalnog (GI) krvarenja te utvrditi razlike u karakteristikama krvarenja kod primjene različitih skupina antikoagulansa. Ispitanici i postupci: U istraživanje su uključeni bolesnici koji su u 2019. godini hospitalizirani zbog manifestnog GI krvarenja ili sideropenične anemije. Podaci su prikupljeni retrospektivnim pregledom baze podataka bolničkog informacijskog sustava. Rezultati: Ispitivani uzorak sastojao se od 337 bolesnika, a primjena antikoagulantne terapije utvrđena je kod četvrtine ispitanika. Od toga, primjena varfarina je zabilježena kod 45, a primjena novih oralnih antikoagulansa (engl. novel oral anticoagulants; NOAC) kod 39 ispitanika. Ispitanici na antikoagulantnoj terapiji bili su značajno stariji naspram onih bez nje. Također, utvrđena je statistički značajna povezanost između primjene antikoagulantne terapije i povećanja učestalosti transfuzije te broja primijenih doza deplazmatiziranih eritrocita (DE). Statistički značajna razlika između promatranih skupina nije pronađena u učestalosti primjene endoskopske hemostaze, kao ni u broju smrtnih ishoda. Također, nije potvrđena statistička različitost između bolesnika na terapiji varfarinom i NOAC-ima. Zaključak: Primjena antikoagulantne terapije povećava težinu GI krvarenja, ali ne utječe na terapijski ishod krvarenja. Iako su rezultati pojedinih studija ukazali na povećanu incidenciju GI krvarenja uz primjenu NOAC-a u usporedbi s primjenom varfarina, klinička obilježja nastalih krvarenja se bitno ne razlikuju.
Abstract (english)
Aim: This study aimed to investigate the influence of anticoagulant drugs on the clinical features of gastrointestinal (GI) bleeding and to determine differences in the treatment and outcome of bleeding with different groups of anticoagulants. Patients and Methods: The study included patients who were hospitalized in 2019 due to visible GI bleeding or sideropenic anemia. Data were collected by retrospective review of the hospital information system database. Results: The study group consisted of 337 patients. One-quarter of the subjects were found to be on anticoagulant therapy. Of these, warfarin was noted in 45 subjects and new oral anticoagulants (NOAC) in 39 subjects. Subjects on anticoagulant therapy were significantly older than those without anticoagulant therapy. They also had an increased frequency and number of administered doses of red cell concentrate (RCC) transfusions. No statistically significant differences were found between the studied groups in the use of therapeutic endoscopy or outcome. No statistical difference was also found between patients on warfarin therapy and NOACs. Conclusion: Anticoagulant therapy increases the severity of GI bleeding but does not affect the therapeutic outcome of bleeding. Although the results of some studies indicated an increased incidence of GI bleeding with NOACs compared with warfarin, the clinical characteristics of the resulting bleeding did not differ significantly.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:756753
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-07-10 10:47:21