A cataract is any blurring of an otherwise transparent lens, and the patient experiences it with blurred vision and the appearance of monocular diplopia. (3) Glaucoma is a chronic progressive optic neuropathy characterized by the decay of ganglion cells within the retina and the loss of axonal fibers in the optic nerve. (1) Pseudoexfoliative syndrome is a systemic disease characterized by the deposition of fibrillar material in the anterior segment of the eye and other organs. This material interferes with the outflow of aqueous humor causing an increase in IOP and the formation of pseudoexfoliative glaucoma which belongs to secondary open-angle glaucoma. (14) The prevalence of PEX glaucoma in PEX syndrome is about 50%. (23) Cataract surgery in patients with PEX glaucoma is a complicated operation that requires an experienced surgeon because there is a higher risk of intraoperative and postoperative complications; and the operation itself is performed with more complexity than cataract surgeries without associated eye diseases. (30) Cataract surgery with PEX glaucoma is most often performed using the phacoemulsification. During the operation, we must pay special attention to the zonal, corneal endothelium, the amount of PEX material in the drainage system and the entire anterior chamber of the eye, and the size of the opening on the anterior capsule of the lens. Intraoperative complications include weak mydriasis, shallow and deep anterior chamber, zonal dialysis and nucleus prolapse. Early postoperative complications include keratopathy, cystoid macular edema, intraocular lens deposits, and intraocular pressure spikes. Late postoperative complications include anterior capsular contraction, posterior capsule fibrosis, and IOL dislocation. (31)