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Scientific paper - Review paper
Type 2 diabetes and viral infection; cause and effect of disease
Diabetes Research and Clinical Practice, 172 (2021); 108637. https://doi.org/10.1016/j.diabres.2020.108637
Turk Wensveen, Tamara; Gašparini, Dora; Rahelić, Dario; Wensveen, Felix M.

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Turk Wensveen, T., Gašparini, D., Rahelić, D. & Wensveen, F. M. (2021). Type 2 diabetes and viral infection; cause and effect of disease. Diabetes Research and Clinical Practice, 172.. doi: 10.1016/j.diabres.2020.108637

Turk Wensveen, Tamara, et al. "Type 2 diabetes and viral infection; cause and effect of disease." Diabetes Research and Clinical Practice, vol. 172, 2021. https://doi.org/10.1016/j.diabres.2020.108637

Turk Wensveen, Tamara, Dora Gašparini, Dario Rahelić and Felix M. Wensveen. "Type 2 diabetes and viral infection; cause and effect of disease." Diabetes Research and Clinical Practice 172 (2021). https://doi.org/10.1016/j.diabres.2020.108637

Turk Wensveen, T., et al. (2021) 'Type 2 diabetes and viral infection; cause and effect of disease', Diabetes Research and Clinical Practice, 172. doi: 10.1016/j.diabres.2020.108637

Turk Wensveen T, Gašparini D, Rahelić D, Wensveen FM. Type 2 diabetes and viral infection; cause and effect of disease. Diabetes Research and Clinical Practice [Internet]. 2021 February [cited 2024 May 05];172. doi: 10.1016/j.diabres.2020.108637

T. Turk Wensveen, D. Gašparini, D. Rahelić and F. M. Wensveen, "Type 2 diabetes and viral infection; cause and effect of disease", Diabetes Research and Clinical Practice, vol. 172, February 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:548244. [Accessed: 05 May 2024]

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Metadata
Title (english)Type 2 diabetes and viral infection; cause and effect of disease
AuthorTamara Turk Wensveen
AuthorDora Gašparini https://orcid.org/0000-0002-0503-9516
AuthorDario Rahelić
AuthorFelix M. Wensveen
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
The recent pandemic of COVID-19 has made abundantly clear that Type 2 diabetes (T2D) increases the risk of more frequent and more severe viral infections. At the same time, pro-inflammatory cytokines of an anti-viral Type-I profile promote insulin resistance and form a risk factor for development of T2D. What this illustrates is that there is a reciprocal, detrimental interaction between the immune and endocrine system in the context of T2D. Why these two systems would interact at all long remained unclear. Recent findings indicate that transient changes in systemic metabolism are induced by the immune system as a strategy against viral infection. In people with T2D, this system fails, thereby negatively impacting the antiviral immune response. In addition, immune-mediated changes in systemic metabolism upon infection may aggravate glycemic control in T2D. In this review, we will discuss recent literature that sheds more light on how T2D impairs immune responses to viral infection and how virus-induced activation of the immune system increases risk of development of T2D.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDiabetes Research and Clinical Practice
Numberingvol. 172, 108637
p-ISSN0168-8227
DOIhttps://doi.org/10.1016/j.diabres.2020.108637
URN:NBNurn:nbn:hr:184:548244
Publication2021-02
ProjectNumber: IP-2016-06-8027
Title (croatian): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva
Acronym: T-MEMORY
Leader: Felix Wensveen
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: IP-CORONA-2020-04-2045
Title (croatian): Manipuliranje imunološkom memorijom: razvoj novih strategija u svrhu stvaranja boljeg memorijskog CD8 T-staničnog odgovora protiv COVID-19 nakon cijepljenja
Leader: Felix Martinus Wensveen
Jurisdiction: Croatia
Funding stream: IP-CORONA
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0168822720308949
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2021-04-19 11:20:53