prikaz prve stranice dokumenta New insights into erythropoietin and erythropoietin receptor in laryngeal cancer tissue
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Scientific paper - Original scientific paper
New insights into erythropoietin and erythropoietin receptor in laryngeal cancer tissue
Medicine, 100 (2021), 3; e23943. https://doi.org/10.1097/MD.0000000000023943
Vukelić, Jelena; Dobrila-Dintinjana, Renata; Marijić, Blažen; Maržić, Diana; Braut, Tamara; Velepič, Marko

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Vukelić, J., Dobrila Dintinjana, R., Marijić, B., Maržić, D., Braut, T. & Velepič, M. (2021). New insights into erythropoietin and erythropoietin receptor in laryngeal cancer tissue. Medicine, 100. (3). doi: 10.1097/MD.0000000000023943

Vukelić, Jelena, et al. "New insights into erythropoietin and erythropoietin receptor in laryngeal cancer tissue." Medicine, vol. 100, no. 3, 2021. https://doi.org/10.1097/MD.0000000000023943

Vukelić, Jelena, Renata Dobrila Dintinjana, Blažen Marijić, Diana Maržić, Tamara Braut and Marko Velepič. "New insights into erythropoietin and erythropoietin receptor in laryngeal cancer tissue." Medicine 100, no. 3 (2021). https://doi.org/10.1097/MD.0000000000023943

Vukelić, J., et al. (2021) 'New insights into erythropoietin and erythropoietin receptor in laryngeal cancer tissue', Medicine, 100(3). doi: 10.1097/MD.0000000000023943

Vukelić J, Dobrila Dintinjana R, Marijić B, Maržić D, Braut T, Velepič M. New insights into erythropoietin and erythropoietin receptor in laryngeal cancer tissue. Medicine [Internet]. 2021 January 22 [cited 2024 December 05];100(3). doi: 10.1097/MD.0000000000023943

J. Vukelić, R. Dobrila Dintinjana, B. Marijić, D. Maržić, T. Braut and M. Velepič, "New insights into erythropoietin and erythropoietin receptor in laryngeal cancer tissue", Medicine, vol. 100, no. 3, January 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:613805. [Accessed: 05 December 2024]

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Metadata
Title (english)New insights into erythropoietin and erythropoietin receptor in laryngeal cancer tissue
AuthorJelena Vukelić
AuthorRenata Dobrila-Dintinjana
AuthorBlažen Marijić
AuthorDiana Maržić
AuthorTamara Braut
AuthorMarko Velepič
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Oncology and Radiotherapy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Otorhinolaryngology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
To investigate whether laryngeal cancer cells express erythropoietin (Epo) and erythropoietin receptor (EpoR) and what is their possible relationship with clinical and pathological features of the tumor. We performed immunohistochemical analysis of Epo and EpoR expression on 78 tissue samples of invasive and in situ squamous cell laryngeal carcinoma. The statistical analysis showed a weak positive and statistically significant correlation of EpoHS and EpoR HS expression levels. Epo HS and EpoR HS levels did not correlate with patient sex or age, type of diagnosis, cancer stage, histological tumor grade, presence or absence of disease recurrence, type of oncologic cancer therapy provided, or results of selected laboratory blood work. The results show a statistically significant difference in Epo expression with respect to survival. We confirmed the presence of Epo an EpoR in malignant laryngeal tumors and demonstrated the correlation between Epo expression and survival. Further studies are needed to more precisely define the role of Epo and EpoR in treatment of patients with laryngeal cancer.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedicine
Numberingvol. 100, no. 3, e23943
p-ISSN0025-7974
e-ISSN1536-5964
DOIhttps://doi.org/10.1097/MD.0000000000023943
URN:NBNurn:nbn:hr:184:613805
Publication2021-01-22
Document URLhttps://journals.lww.com/10.1097/MD.0000000000023943
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2021-02-18 21:00:27