prikaz prve stranice dokumenta Overall survival and disease control rates for operable invasive breast cancer in the era of conservative surgery; retrospective, institutional, and five-year follow-up data
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Overall survival and disease control rates for operable invasive breast cancer in the era of conservative surgery; retrospective, institutional, and five-year follow-up data
Libri Oncologici : Croatian Journal of Oncology, 48 (2020), 2-3; 61-67. https://doi.org/10.20471/LO.2020.48.02-03.11
Car Peterko, Ana; Avirović, Manuela; Skočilić, Iva; Valković-Zujić, Petra; Belac-Lovasić, Ingrid; Lovasić, Franjo

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Car Peterko, A., Avirović, M., Skočilić, I., Valković Zujić, P., Belac Lovasić, I. & Lovasić, F. (2020). Overall survival and disease control rates for operable invasive breast cancer in the era of conservative surgery; retrospective, institutional, and five-year follow-up data. Libri Oncologici : Croatian Journal of Oncology, 48. (2-3), 61-67. doi: 10.20471/LO.2020.48.02-03.11

Car Peterko, Ana, et al. "Overall survival and disease control rates for operable invasive breast cancer in the era of conservative surgery; retrospective, institutional, and five-year follow-up data." Libri Oncologici : Croatian Journal of Oncology, vol. 48, no. 2-3, 2020, pp. 61-67. https://doi.org/10.20471/LO.2020.48.02-03.11

Car Peterko, Ana, Manuela Avirović, Iva Skočilić, Petra Valković Zujić, Ingrid Belac Lovasić and Franjo Lovasić. "Overall survival and disease control rates for operable invasive breast cancer in the era of conservative surgery; retrospective, institutional, and five-year follow-up data." Libri Oncologici : Croatian Journal of Oncology 48, no. 2-3 (2020): 61-67. https://doi.org/10.20471/LO.2020.48.02-03.11

Car Peterko, A., et al. (2020) 'Overall survival and disease control rates for operable invasive breast cancer in the era of conservative surgery; retrospective, institutional, and five-year follow-up data', Libri Oncologici : Croatian Journal of Oncology, 48(2-3), pp. 61-67. doi: 10.20471/LO.2020.48.02-03.11

Car Peterko A, Avirović M, Skočilić I, Valković Zujić P, Belac Lovasić I, Lovasić F. Overall survival and disease control rates for operable invasive breast cancer in the era of conservative surgery; retrospective, institutional, and five-year follow-up data. Libri Oncologici : Croatian Journal of Oncology [Internet]. 2020 [cited 2024 November 19];48(2-3):61-67. doi: 10.20471/LO.2020.48.02-03.11

A. Car Peterko, M. Avirović, I. Skočilić, P. Valković Zujić, I. Belac Lovasić and F. Lovasić, "Overall survival and disease control rates for operable invasive breast cancer in the era of conservative surgery; retrospective, institutional, and five-year follow-up data", Libri Oncologici : Croatian Journal of Oncology, vol. 48, no. 2-3, pp. 61-67, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:256035. [Accessed: 19 November 2024]

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Metadata
Title (english)Overall survival and disease control rates for operable invasive breast cancer in the era of conservative surgery; retrospective, institutional, and five-year follow-up data
Title (croatian)Operabilni invazivni karcinom dojke u eri konzervativne kirurgije; retrospektivna analiza 5-godišnjeg preživljenja i kontrole bolesti
AuthorAna Car Peterko
MBZ: 310186
AuthorManuela Avirović
AuthorIva Skočilić
AuthorPetra Valković-Zujić
AuthorIngrid Belac-Lovasić
AuthorFranjo Lovasić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Oncology and Radiotherapy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Radiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
Background: Following breast cancer treatment recommendations, the conservative approach is accepted and highly respected in the Clinical Hospital Center (CHC) Rijeka. However, we have found that institutional follow-up data are lacking. This retrospective analysis aims to update institutional data on survival and disease control rates. Methods: From 2011 till 2014, 915 breast cancer patients underwent surgery at CHC Rijeka, and 615 were included in this analysis. The Institutional Ethics Committee approved the analysis. Results: All patients were female, and the average age was 59 years. In the 5-year postoperative period, local, regional, and distant recurrence-free survival rates and overall survival and disease-free survival were calculated. All rates negatively correlate with a higher T and N status and a higher stage of the disease. The analysis has also demonstrated that in the pT1-3 pN0-1 subgroup, sentinel lymph node biopsy (SLNB) was not inferior to axillary lymph node dissection (ALND) in terms of locoregional control of disease and overall survival. Conclusion: Besides updating institutional data, the analysis confirmed that overall survival and locoregional control of the disease in the upfront-surgery patients are similar between pN0 and pN1 subpopulations and between pN2 and pN3, but statistically significantly different between pN0-1 and pN2-3. Currently ongoing, prospective observational multicenter clinical trial aims to translate the significance of these results into the neoadjuvant era.
Abstract (croatian)
Uvod: Temeljem suvremenih preporuka za liječenje karcinoma dojke, u Kliničkom bolničkom centru (KBC) Rijeka prihvaća se i zagovara konzervativni kirurški pristup. Međutim, na razini naše institucije, ali i na nacionalnom nivou, malo je obrađenih rezultata liječenja. Cilj ove retrospektivne analize je ažuriranje institucionalnih podataka o preživljenju i kontroli bolesti. Metode: U periodu od 2011. do 2014. godine, u KBC Rijeka operirano je 915 pacijentica oboljelih od karcinoma dojke, a njih 615 uključeno je u ovu analizu. Istraživanje je odobreno od Etičkog povjerenstva KBC Rijeka. Rezultati: Sve su pacjentice bile žene, prosječno stare 59 godina. Izračunate su ukupne stope preživljenja bez lokalnog, regionalnog i udaljenog recidiva, te stope ukupnog preživljenja i preživljenja bez povrata bolesti u petogodišnjem postoperativnom periodu. Sve su stope u negativnoj korelaciji sa višim T i N statusom kao i višim stadijem bolesti. Osim navedenog, rezultati su potvrdili da je biopsija sentinel limfnog čvora ekvivalentna aksilarnoj disekciji u smislu lokoregionalne kontrole bolesti kao i ukupnog petogodišnjeg preživljenja u pT1-3 pN0-1 podskupini. Zaključak: Osim ažuriranja podataka naše institucije, ova je analiza potvrdila da su stope preživljenja i lokoregionalne kontrole bolesti u eri primarnog kirurškog tretmana slične između pN0 i pN1 subpopulacija kao i među pN2 i pN3, međutim statistički značajno različite između pN0-1 I pN2-3 podskupina. Prospektivno, opservacijsko, multicentrično kliničko istraživanje koje je u tijeku pokušava istražiti značenje ovih rezultata u neoadjuvantoj eri.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeProfessional paper - Professional paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleLibri Oncologici : Croatian Journal of Oncology
Numberingvol. 48, no. 2-3, pp. 61-67
p-ISSN0300-8142
e-ISSN2584-3826
DOIhttps://doi.org/10.20471/LO.2020.48.02-03.11
URN:NBNurn:nbn:hr:184:256035
Publication2020
Document URLhttps://hrcak.srce.hr/250271
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2021-01-20 12:41:43