Introduction: Colorectal cancer is a malignant tumor originating from the glandular epithelium of the colonic mucosa. It is the fourth most common cancer and the third leading cause of cancer death in the world. The risk of developing CRC is influenced by a number of etiological factors. The incidence is significantly higher after the age of 50 and in males. Tumor stage significantly affects survival. Purpose: The aim of this study was to determine whether there is a shift in the diagnosis of CRC between 2008 and 2018 at the University Hospital Center Rijeka. Also, to analyze the clinical and pathological characteristics and the most common localizations of colorectal cancer and compare its frequency with sex and age. Furthermore, analyze the relationship of tumor localization and size to stage of the disease. Subjects and methods: This retrospective study includes patients of KBC Rijeka with the initial diagnosis of CRC in years 2008 and 2018 . The study included 215 patients from 2008 and 224 patients from 2018. Results: The obtained results showed that the incidence of CRC is higher in males and that 95% of this cancer occurs after the age of 50. The most common localization of the primary site of CRC is the rectum, followed by the left colon. The majority of diagnosed CRCs are of low grade and classic adenocarcinomas (NOS). Comparing 2008 and 2018, we conclude that the number of low stages increased by 21 and high stages lowered by 12, at a statistically significant level. Conclusion: From the above data and results, it can be concluded that there is a shift in the earlier diagnosis of colorectal cancer in 2018, compared to 2008 in KBC Rijeka.