Globally, breast cancer is the most frequently diagnosed malignancy and the leading cause of cancer death in women. The risk of breast cancer increases with older age. Knowledge of pathological lesions in the breast is extremely important in order to begin monitoring or treatment of patients as soon as possible. Breast lesions can be divided into benign and malignant lesions. The diagnosis of breast pathology, after a systematic anamnesis and physical examination, is followed by imaging methods by which we will know in more detail what kind of lesion it is. The main method of detecting malignant lesions is mammography. Finally, we will decide on possible cytological and pathohistological methods. Percutaneous breast biopsy is widely practised to evaluate suspicious breast lesions. The primary goal of core needle biopsy (CNB) is to send a visible or suspicious lesion found by radiological methods or physical examination for pathohistological analysis to arrive at a definitive diagnosis, but also to avoid surgery for possible benign lesions and not expose the patient to a major stressor. Ultrasound is the method of choice for guiding biopsy management because it is simple, fastest, and least harmful to patients. The only absolute contraindications are refusal of intervention and lesions that are not visible on the present ultrasound. Minor pain in the biopsy area is most common and rare complications that may occur are hematoma or infection. In 2 % of cases of wide-needle biopsy, although the frequency is lower compared to other methods, false negative results can occur. Wide-needle biopsy is a sufficiently valuable and sufficient method for accurate diagnosis.