The aim of this work was to research the literature which is focused on the oral care of the children with disabilities. For the purpose of this work the chosen population were children with one of the diagnosis: Down Syndrome, Cerebral paralyses or Autism. Oral hygiene is preventive discipline which is focused on the health promotion and prevention of dental diseases. Dental intervention in the health children population is a challenge if not prepared properly, and especially in the children with disabilities. In this work the literature research of national and international sources was preformed with the focus on the oral hygiene in children with disabilities. The results of literature research showed a lot of options and possibilities for the adjustment with the main goal of better oral hygiene of children with disabilities and modifications of approach of dental team, but also the cooperation with the parents is necessary. In conclusion, with the respect of the main rules of oral hygiene in general population it is necessary to adapt the approach for achieving the best results of oral hygiene in children with disabilities. The literature shows a lot of possibilities like a modified hand grip for toothbrush, rinsing with mouth wash, educational literature for children, etc.