prikaz prve stranice dokumenta Perforin expression in peripheral blood lymphatic cells of patients subjected to laparoscopic or open cholecystectomy
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Scientific paper - Original scientific paper
Perforin expression in peripheral blood lymphatic cells of patients subjected to laparoscopic or open cholecystectomy
Mediators of inflammation, 2009 (2009); 1-11. https://doi.org/10.1155/2009/125152
Grbas, Harry; Mrakovčić-Šutić, Ines; Depolo, Arsen; Radošević-Stašić, Biserka

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Grbas, H., Mrakovčić Šutić, I., Depolo, A. & Radošević Stašić, B. (2009). Perforin expression in peripheral blood lymphatic cells of patients subjected to laparoscopic or open cholecystectomy. Mediators of inflammation, 2009., 1-11. doi: 10.1155/2009/125152

Grbas, Harry, et al. "Perforin expression in peripheral blood lymphatic cells of patients subjected to laparoscopic or open cholecystectomy." Mediators of inflammation, vol. 2009, 2009, pp. 1-11. https://doi.org/10.1155/2009/125152

Grbas, Harry, Ines Mrakovčić Šutić, Arsen Depolo and Biserka Radošević Stašić. "Perforin expression in peripheral blood lymphatic cells of patients subjected to laparoscopic or open cholecystectomy." Mediators of inflammation 2009 (2009): 1-11. https://doi.org/10.1155/2009/125152

Grbas, H., et al. (2009) 'Perforin expression in peripheral blood lymphatic cells of patients subjected to laparoscopic or open cholecystectomy', Mediators of inflammation, 2009, pp. 1-11. doi: 10.1155/2009/125152

Grbas H, Mrakovčić Šutić I, Depolo A, Radošević Stašić B. Perforin expression in peripheral blood lymphatic cells of patients subjected to laparoscopic or open cholecystectomy. Mediators of inflammation [Internet]. 2009 [cited 2025 February 27];2009:1-11. doi: 10.1155/2009/125152

H. Grbas, I. Mrakovčić Šutić, A. Depolo and B. Radošević Stašić, "Perforin expression in peripheral blood lymphatic cells of patients subjected to laparoscopic or open cholecystectomy", Mediators of inflammation, vol. 2009, pp. 1-11, 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:426294. [Accessed: 27 February 2025]

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Metadata
Title (english)Perforin expression in peripheral blood lymphatic cells of patients subjected to laparoscopic or open cholecystectomy
AuthorHarry Grbas
AuthorInes Mrakovčić-Šutić
AuthorArsen Depolo
AuthorBiserka Radošević-Stašić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Perforin (P)-related characteristics of cytotoxic T lymphocytes and natural killer cells were investigated in peripheral blood of patients subjected to open (OC ; n=23) or laparoscopic cholecystectomy (LC ; n=21) and healthy controls (n=20). Blood samples were obtained preoperatively and 24 h after the surgeries and the data were correlated with the intensity of cholestasis and concomitant inflammation, determined by functional hepatic tests. Postoperative differences were found to be minimal: OC decreased only the percentage of CD56+ cells, while LC decreased the fraction of CD8+P+ cells and augmented the mean fluorescence intensity of P in CD56 cells. Patients elected for OC had, however, higher preoperative numbers of total P+, CD3+P+ and CD4+P+ cells than patients elected for LC and healthy controls, while both groups of patients, preoperatively, had lower fraction of CD16+P+ and CD56+P+ cells. These changes were in high correlation with blood concentrations of CRP, AP and ALT, emphasizing the link between the preoperative cholestasis and inflammation and P-dependent cytotoxic mechanisms.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMediators of inflammation
Numberingvol. 2009, pp. 1-11
p-ISSN0962-9351
DOIhttps://doi.org/10.1155/2009/125152
URN:NBNurn:nbn:hr:184:426294
Publication2009
ProjectNumber: 062-0620096-0094
Title (croatian): Regulacijske T i NKT stanice u kontroli tumorskog rasta, opeklina i autoimunosti
Leader: Ines Mrakovčić-Šutić
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0621341-1337
Title (croatian): Morfogenetska svojstva stresnih proteina gp96 i metalotioneina
Leader: Biserka Radošević-Stašić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://bib.irb.hr/332702
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-04-08 10:00:44