prikaz prve stranice dokumenta Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals
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Scientific paper - Original scientific paper
Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals
Journal of clinical medicine, 9 (2020), 3; 843-852. https://doi.org/10.3390/jcm9030843
Barić, Lidija; Drenjančević, Ines; Mihalj, Martina; Matić, Anita; Stupin, Marko; Kolar, Luka; Mihaljević, Zrinka; Mrakovčić-Šutić, Ines; Šerić, Vatroslav; Stupin, Ana

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Barić, L., Drenjančević, I., Mihalj, M., Matić, A., Stupin, M., Kolar, L. ... Stupin, A. (2020). Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals. Journal of clinical medicine, 9. (3), 843-852. doi: 10.3390/jcm9030843

Barić, Lidija, et al. "Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals." Journal of clinical medicine, vol. 9, no. 3, 2020, pp. 843-852. https://doi.org/10.3390/jcm9030843

Barić, Lidija, Ines Drenjančević, Martina Mihalj, Anita Matić, Marko Stupin, Luka Kolar, Zrinka Mihaljević, Ines Mrakovčić Šutić, Vatroslav Šerić and Ana Stupin. "Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals." Journal of clinical medicine 9, no. 3 (2020): 843-852. https://doi.org/10.3390/jcm9030843

Barić, L., et al. (2020) 'Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals', Journal of clinical medicine, 9(3), pp. 843-852. doi: 10.3390/jcm9030843

Barić L, Drenjančević I, Mihalj M, Matić A, Stupin M, Kolar L, and sur.. Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals. Journal of clinical medicine [Internet]. 2020 [cited 2024 December 05];9(3):843-852. doi: 10.3390/jcm9030843

L. Barić, et al., "Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals", Journal of clinical medicine, vol. 9, no. 3, pp. 843-852, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:085058. [Accessed: 05 December 2024]

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Metadata
Title (english)Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals
AuthorLidija Barić
AuthorInes Drenjančević
MBZ: 209603
AuthorMartina Mihalj
MBZ: 322792
AuthorAnita Matić
MBZ: 326344
AuthorMarko Stupin
MBZ: 367386
AuthorLuka Kolar
AuthorZrinka Mihaljević
MBZ: 324952
AuthorInes Mrakovčić-Šutić
AuthorVatroslav Šerić
MBZ: 193563
AuthorAna Stupin
MBZ: 322935
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
This study aimed to examine whether the oral supplementation of vitamins C and E during 7- days high salt diet (HS ; ~14 g salt/day) prevents microvascular endothelial function impairment and changes oxidative status caused by HS diet in 51 (26 women and 25 men) young healthy individuals. Laser Doppler flowmetry measurements demonstrated that skin post- occlusive reactive hyperemia (PORH), and acetylcholine-induced dilation (AChID) were significantly impaired in HS group, but not in HS+C+E group, while sodium nitroprusside- induced dilation remained unaffected by treatments. Serum oxidative stress markers: TBARS, 8-iso prostaglandin-F2α and leukocytes’ intracellular H2O2 production were significantly increased, while ferric-reducing ability of plasma (FRAP) and catalase concentrations were decreased in HS group. All these parameters remained unaffected by vitamins supplementation. Matrix metalloproteinase 9, antioxidant enzymes Cu/Zn SOD and glutathione peroxidase 1, and leukocytes’ intracellular superoxide production remained unchanged after the protocols in both HS and HS+C+E groups. Importantly, multiple regression analysis revealed that FRAP was the most powerful predictor of AChID, while PORH was strongly predicted by both FRAP and renin- angiotensin system activity. Hereby, we demonstrated that oxidative dis-balance has the pivotal role in HS diet-induced impairment of endothelial and microvascular function in healthy individuals which could be prevented by antioxidative vitamins consumption.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of clinical medicine
Numberingvol. 9, no. 3, pp. 843-852
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm9030843
URN:NBNurn:nbn:hr:184:085058
Publication2020
ProjectNumber: IP-2016-06-8744
Title (croatian): Interakcija renin-angiotenzinskog i adrenergičkog sustava u aktivaciji endotela uzrokovanoj oksidativnim stresom
Acronym: RAS-AdrenOX
Leader: Ana Stupin rođ. Čavka
Jurisdiction: Croatia
Funding stream: IP
Document URLhttp://bib.irb.hr/1054795
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-03-31 14:47:04