prikaz prve stranice dokumenta Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling
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Scientific paper - Case study
Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling
Diabetes Care, 43 (2019), 2; 494-196. https://doi.org/10.2337/dc19-1888
Turk Wensveen, Tamara; Fučkar Čupić, Dora; Jurišić Eržen, Dubravka; Polić, Bojan; Wensveen, Felix M.

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Turk Wensveen, T., Fučkar Čupić, D., Jurišić Eržen, D., Polić, B. & Wensveen, F. M. (2019). Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling. Diabetes Care, 43. (2), 494-196. doi: 10.2337/dc19-1888

Turk Wensveen, Tamara, et al. "Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling." Diabetes Care, vol. 43, no. 2, 2019, pp. 494-196. https://doi.org/10.2337/dc19-1888

Turk Wensveen, Tamara, Dora Fučkar Čupić, Dubravka Jurišić Eržen, Bojan Polić and Felix M. Wensveen. "Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling." Diabetes Care 43, no. 2 (2019): 494-196. https://doi.org/10.2337/dc19-1888

Turk Wensveen, T., et al. (2019) 'Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling', Diabetes Care, 43(2), pp. 494-196. doi: 10.2337/dc19-1888

Turk Wensveen T, Fučkar Čupić D, Jurišić Eržen D, Polić B, Wensveen FM. Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling. Diabetes Care [Internet]. 2019 [cited 2024 May 07];43(2):494-196. doi: 10.2337/dc19-1888

T. Turk Wensveen, D. Fučkar Čupić, D. Jurišić Eržen, B. Polić and F. M. Wensveen, "Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling", Diabetes Care, vol. 43, no. 2, pp. 494-196, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:925629. [Accessed: 07 May 2024]

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Metadata
Title (english)Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling
AuthorTamara Turk Wensveen
AuthorDora Fučkar Čupić
AuthorDubravka Jurišić Eržen
AuthorBojan Polić
AuthorFelix M. Wensveen
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
CASE SUMMARY A female patient age 69 years with .10-year history of type 2 diabetes (T2D), on a therapy of premixed aspart insulin, presented with poor glycemic control (HbA1c 8.7%). Change of therapy to three injections of short- acting aspart and once-daily glargine improved glycemic control but resulted in severe lipoatrophy at all sites of injection, a rare complication of insulin therapy almost exclusively associated with type 1 diabetes (T1D). The patient had C-peptide levels within normal range and lacked autoantibodies against GAD, islet antigen 2 (IA-2), and tissue transglutaminase (tTg), excluding T1D. Glargine injection was replaced by degludec, but this did not prevent formation of new indentures. Histological analysis of tissue biopsies revealed strong tissue remodeling at affected sites including fibrosis, reduction of adipocyte size, and increased vascularization. Immunohistochemical staining showed a strong influx of CD4 T cells in affected sites but no apparent signs of T cell–mediated cell death. Flow cytometry of peripheral blood leukocytes did not show an overt effector cell profile of CD4 T cells, indicating that the response was mediated locally. Our findings indicate that insulin-induced lipoatrophy in the context of T2D is distinct from that seen in T1D and appears to depend on CD4 T cell–mediated tissue remodeling.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDiabetes Care
Numberingvol. 43, no. 2, pp. 494-196
p-ISSN0149-5992
DOIhttps://doi.org/10.2337/dc19-1888
URN:NBNurn:nbn:hr:184:925629
Publication2019
ProjectNumber: IP-2016-06-9306
Title (croatian): Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini
Acronym: INFLAMETAB
Leader: Bojan Polić
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: IP-2016-06-8027
Title (croatian): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva
Acronym: T-MEMORY
Leader: Felix Wensveen
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: uniri-biomed-18-117
Title (croatian): Direktni utjecaj hipoglikemija na promjene srčanog ritma u bolesnika sa šećernom bolesti tip 2
Title (english): Direct impact of hypoglycaemia on heart rhythm in patients with diabetes mellitus type 2
Leader: Tamara Turk Wensveen
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
Document URLhttp://bib.irb.hr/1047236
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2020-03-30 08:31:25