prikaz prve stranice dokumenta The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors
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Scientific paper - Original scientific paper
The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors
The Journal of Experimental Medicine, 216 (2019), 8; 1809-1827. https://doi.org/10.1084/jem.20182213
Železnjak, Jelena; Lisnić, Vanda Juranić; Popović, Branka; Lisnić, Berislav; Babić, Marina; Halenius, Anne; L’Hernault, Anne; Roviš, Tihana Lenac; Hengel, Hartmut; Erhard, Florian; Redwood, Alec J.; Vidal, Silvia M.; Dölken, Lars; Krmpotić, Astrid; Jonjić, Stipan More authors...

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Železnjak, J., Lisnić, V. J., Popović, B., Lisnić, B., Babić, M., Halenius, A. ... Jonjić, S. (2019). The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors. The Journal of Experimental Medicine, 216. (8), 1809-1827. doi: 10.1084/jem.20182213

Železnjak, Jelena, et al. "The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors." The Journal of Experimental Medicine, vol. 216, no. 8, 2019, pp. 1809-1827. https://doi.org/10.1084/jem.20182213

Železnjak, Jelena, Vanda Juranić Lisnić, Branka Popović, Berislav Lisnić, Marina Babić, Anne Halenius, Anne L’Hernault, et al. "The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors." The Journal of Experimental Medicine 216, no. 8 (2019): 1809-1827. https://doi.org/10.1084/jem.20182213

Železnjak, J., et al. (2019) 'The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors', The Journal of Experimental Medicine, 216(8), pp. 1809-1827. doi: 10.1084/jem.20182213

Železnjak J, Lisnić VJ, Popović B, Lisnić B, Babić M, Halenius A, and sur.. The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors. The Journal of Experimental Medicine [Internet]. 2019 August 05 [cited 2024 December 31];216(8):1809-1827. doi: 10.1084/jem.20182213

J. Železnjak, et al., "The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors", The Journal of Experimental Medicine, vol. 216, no. 8, pp. 1809-1827, August 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:650034. [Accessed: 31 December 2024]

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Metadata
Title (english)The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors
AuthorJelena Železnjak
AuthorVanda Juranić Lisnić
AuthorBranka Popović
AuthorBerislav Lisnić
AuthorMarina Babić
AuthorAnne Halenius
AuthorAnne L’Hernault
AuthorTihana Lenac Roviš
AuthorHartmut Hengel
AuthorFlorian Erhard
AuthorAlec J. Redwood
AuthorSilvia M. Vidal
AuthorLars Dölken
AuthorAstrid Krmpotić
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
CMVs efficiently target MHC I molecules to avoid recognition by cytotoxic T cells. However, the lack of MHC I on the cell surface renders the infected cell susceptible to NK cell killing upon missing self recognition. To counter this, mouse CMV (MCMV) rescues some MHC I molecules to engage inhibitory Ly49 receptors. Here we identify a new viral protein, MATp1, that is essential for MHC I surface rescue. Rescued altered-self MHC I molecules show increased affinity to inhibitory Ly49 receptors, resulting in inhibition of NK cells despite substantially reduced MHC I surface levels. This enables the virus to evade recognition by licensed NK cells. During evolution, this novel viral immune evasion mechanism could have prompted the development of activating NK cell receptors that are specific for MATp1-modified altered-self MHC I molecules. Our study solves a long-standing conundrum of how MCMV avoids recognition by NK cells, unravels a fundamental new viral immune evasion mechanism, and demonstrates how this forced the evolution of virus-specific activating MHC I–restricted Ly49 receptors.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleThe Journal of Experimental Medicine
Numberingvol. 216, no. 8, pp. 1809-1827
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.20182213
URN:NBNurn:nbn:hr:184:650034
Publication2019-08-05
ProjectNumber: G1002523
Title (english): Regulatory role of non-coding RNAs in herpesvirus infections
Jurisdiction: United Kingdom
Funding stream: MRC
ProjectNumber: KK.011.1.01.0006
Title (croatian): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: Croatia
ProjectNumber: N/A
Title (croatian): Centar izvrsnosti za virusnu imunologiju i cjepiva
Title (english): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Acronym: CERVirVac
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZCI
Document URLhttps://rupress.org/jem/article/216/8/1809/120585/The-complex-of-MCMV-proteins-and-MHC-class-I
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) icon
Created on2020-02-19 16:24:25