prikaz prve stranice dokumenta Epidemiological and clinical features of primary biliary cholangitis in two Croatian regions: a retrospective study
  Download
PDF 454.18 KB
Scientific paper - Original scientific paper
Epidemiological and clinical features of primary biliary cholangitis in two Croatian regions: a retrospective study
Croatian Medical Journal, 60 (2019), 6; 494-502. https://doi.org/10.3325/cmj.2019.60.494
Madir, Anita; Božin, Tonći; Mikolašević, Ivana; Milić, Sandra; Štimac, Davor; Mijić, Maja; Filipec Kanižaj, Tajana; Biloglav, Zrinka; Lucijanić, Marko; Lucijanić, Iva; Grgurević, Ivica

Citations:
,
Cite this document

Madir, A., Božin, T., Mikolašević, I., Milić, S., Štimac, D., Mijić, M. ... Grgurević, I. (2019). Epidemiological and clinical features of primary biliary cholangitis in two Croatian regions: a retrospective study. Croatian Medical Journal, 60. (6), 494-502. doi: 10.3325/cmj.2019.60.494

Madir, Anita, et al. "Epidemiological and clinical features of primary biliary cholangitis in two Croatian regions: a retrospective study." Croatian Medical Journal, vol. 60, no. 6, 2019, pp. 494-502. https://doi.org/10.3325/cmj.2019.60.494

Madir, Anita, Tonći Božin, Ivana Mikolašević, Sandra Milić, Davor Štimac, Maja Mijić, Tajana Filipec Kanižaj, et al. "Epidemiological and clinical features of primary biliary cholangitis in two Croatian regions: a retrospective study." Croatian Medical Journal 60, no. 6 (2019): 494-502. https://doi.org/10.3325/cmj.2019.60.494

Madir, A., et al. (2019) 'Epidemiological and clinical features of primary biliary cholangitis in two Croatian regions: a retrospective study', Croatian Medical Journal, 60(6), pp. 494-502. doi: 10.3325/cmj.2019.60.494

Madir A, Božin T, Mikolašević I, Milić S, Štimac D, Mijić M, and sur.. Epidemiological and clinical features of primary biliary cholangitis in two Croatian regions: a retrospective study. Croatian Medical Journal [Internet]. 2019 December [cited 2025 March 20];60(6):494-502. doi: 10.3325/cmj.2019.60.494

A. Madir, et al., "Epidemiological and clinical features of primary biliary cholangitis in two Croatian regions: a retrospective study", Croatian Medical Journal, vol. 60, no. 6, pp. 494-502, December 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:873201. [Accessed: 20 March 2025]

Please login to the repository to save this object to your list.
Metadata
Title (english)Epidemiological and clinical features of primary biliary cholangitis in two Croatian regions: a retrospective study
AuthorAnita Madir
AuthorTonći Božin
AuthorIvana Mikolašević
AuthorSandra Milić
AuthorDavor Štimac
AuthorMaja Mijić
AuthorTajana Filipec Kanižaj
AuthorZrinka Biloglav
AuthorMarko Lucijanić
AuthorIva Lucijanić
AuthorIvica Grgurević
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Aim To assess the measures of disease frequency and determine the clinical features of primary biliary cholangitis (PBC) in two Croatian regions. Methods Databases of two tertiary hospitals, one located in the continental and one in the coastal region of Croatia, were retrospectively searched for PBC patients diagnosed from 2007 to 2018. Epidemiologic data analysis was restricted to patients from each hospital’s catchment area. We analyzed factors related to response to therapy and event-free... More survival (EFS), defined as absence of ascites, variceal bleeding, encephalopathy, hepatocellular carcinoma, liver transplantation (LT), or death. In addition, we determined clinical and demographic data of transplanted PBC patients. Results Out of 83 PBC patients, 86.7% were female, with a median age at diagnosis of 55 years. Average PBC incidence for the 11-year period was 0.79 and 0.89 per 100 000 population, whereas the point prevalence on December 31, 2017 was 11.5 and 12.5 in the continental and coastal region, respectively. Of 76 patients with complete medical records, 21% had an advanced disease stage, 31.6% had an associated autoimmune condition, and all received ursodeoxycholic acid. EFS rate at 5 years was 95.8%. In an age and sex-adjusted multivariate Cox regression model, the only factor significantly associated with inferior EFS was no response to therapy (HR = 18.4; P = 0.018). Of all Croatian patients who underwent LT, 3.8% had PBC, with the survival rate at 5 years after LT of 93.4%. Conclusion This study gives pioneer insights into the epidemiological and clinical data on PBC in Croatia, thus complementing the PBC map of Southeast Europe. Less
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 60, no. 6, pp. 494-502
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2019.60.494
URN:NBNurn:nbn:hr:184:873201
Publication2019-12
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952898/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-01-23 13:42:55
accessibility

closeAccessibilityrefresh

If you wish to permanently save changes, click on Save, if not - your settings will be reset when you restart the browser.