Respiratory infections make most of all the diseases in children and most of the antibiotics are prescribred for these diseases. The management of the common cold consists primarily of supportive care. There is no evidence that the common cold of less than 10 days in duration benefits from antibiotics. The main goal in treating acute sinusitis is to facilitate draining and infection supervision.Antibiotics in acute and chronic sinusitis are taken for atleast 10 days, often even 14 days.Specific therapy is unavailable for most viral pharyngitis. However, nonspecific, symptomatic therapy can be an important part of the overall treatment plan. Antibiotic therapy of bacterial pharyngitis depends on the organism identified. Treatment options for retropharyngeal abscess, lateral pharyngeal abscess, include intravenous antibiotics with or without surgical drainage. A third-generation cephalosporin combined with ampicillin-sulbactam or clindamycin are used in the treatment. The mainstay of treatment for children with croup is airway management and treatment of hypoxia. Antibiotics are not indicated in croup. In otitis media antibiotic treatment speeds up the resolve of the symptoms and can decrease the possibility of hearing loss and repercussions on the labirinth or intracranial structures.