prikaz prve stranice dokumenta Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge
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Scientific paper - Original scientific paper
Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge
PLOS Pathogens, 15 (2019), 9; e1008036. https://doi.org/10.1371/journal.ppat.1008036
Zheng, Xiaoyan; Oduro, Jennifer D.; Boehme, Julia D.; Borkner, Lisa; Ebensen, Thomas; Heise, Ulrike; Gereke, Marcus; Pils, Marina C.; Krmpotic, Astrid; Guzmán, Carlos A.; Bruder, Dunja; Čičin-Šain, Luka

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Zheng, X., Oduro, J. D., Boehme, J. D., Borkner, L., Ebensen, T., Heise, U. ... Čičin Šain, L. (2019). Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge. PLOS Pathogens, 15. (9). doi: 10.1371/journal.ppat.1008036

Zheng, Xiaoyan, et al. "Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge." PLOS Pathogens, vol. 15, no. 9, 2019. https://doi.org/10.1371/journal.ppat.1008036

Zheng, Xiaoyan, Jennifer D. Oduro, Julia D. Boehme, Lisa Borkner, Thomas Ebensen, Ulrike Heise, Marcus Gereke, et al. "Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge." PLOS Pathogens 15, no. 9 (2019). https://doi.org/10.1371/journal.ppat.1008036

Zheng, X., et al. (2019) 'Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge', PLOS Pathogens, 15(9). doi: 10.1371/journal.ppat.1008036

Zheng X, Oduro JD, Boehme JD, Borkner L, Ebensen T, Heise U, and sur.. Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge. PLOS Pathogens [Internet]. 2019 September 16 [cited 2024 December 25];15(9). doi: 10.1371/journal.ppat.1008036

X. Zheng, et al., "Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge", PLOS Pathogens, vol. 15, no. 9, September 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:304219. [Accessed: 25 December 2024]

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Metadata
Title (english)Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge
AuthorXiaoyan Zheng
AuthorJennifer D. Oduro
AuthorJulia D. Boehme
AuthorLisa Borkner
AuthorThomas Ebensen
AuthorUlrike Heise
AuthorMarcus Gereke
AuthorMarina C. Pils
AuthorAstrid Krmpotic
AuthorCarlos A. Guzmán
AuthorDunja Bruder
AuthorLuka Čičin-Šain
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Cytomegalovirus (CMV) is a ubiquitous β-herpesvirus that establishes life-long latent infection in a high percentage of the population worldwide. CMV induces the strongest and most durable CD8+ T cell response known in human clinical medicine. Due to its unique properties, the virus represents a promising candidate vaccine vector for the induction of persistent cellular immunity. To take advantage of this, we constructed a recombinant murine CMV (MCMV) expressing an MHC-I restricted epitope from influenza A virus (IAV) H1N1 within the immediate early 2 (ie2) gene. Only mice that were immunized intranasally (i.n.) were capable of controlling IAV infection, despite the greater potency of the intraperitoneally (i.p.) vaccination in inducing a systemic IAV-specific CD8+ T cell response. The protective capacity of the i.n. immunization was associated with its ability to induce IAV-specific tissue-resident memory CD8+ T (CD8TRM) cells in the lungs. Our data demonstrate that the protective effect exerted by the i.n. immunization was critically mediated by antigen-specific CD8+ T cells. CD8TRM cells promoted the induction of IFNγ and chemokines that facilitate the recruitment of antigen-specific CD8+ T cells to the lungs. Overall, our results showed that locally applied MCMV vectors could induce mucosal immunity at sites of entry, providing superior immune protection against respiratory infections.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePLOS Pathogens
Numberingvol. 15, no. 9, e1008036
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1008036
URN:NBNurn:nbn:hr:184:304219
Publication2019-09-16
ProjectNumber: 260934
Title (english): Molecular mechanisms of persistent antigenic stimulation in cytomegalovirus infection
Acronym: CMVAGSTIMULUS
Jurisdiction: eu
Funding stream: FP7
Document URLhttp://dx.plos.org/10.1371/journal.ppat.1008036
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2019-11-19 16:33:50