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Scientific paper - Original scientific paper
Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity
Immunity, 49 (2018), 1; 164-177. https://doi.org/10.1016/j.immuni.2018.05.005
Šestan, Marko; Marinović, Sonja; Kavazović, Inga; Cekinović, Đurđica; Wueest, Stephan; Turk Wensveen, Tamara; Brizić, Ilija; Jonjić, Stipan; Konrad, Daniel; Wensveen, Felix M; Polić, Bojan

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Šestan, M., Marinović, S., Kavazović, I., Cekinović, Đ., Wueest, S., Turk Wensveen, T. ... Polić, B. (2018). Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity. Immunity, 49. (1), 164-177. doi: 10.1016/j.immuni.2018.05.005

Šestan, Marko, et al. "Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity." Immunity, vol. 49, no. 1, 2018, pp. 164-177. https://doi.org/10.1016/j.immuni.2018.05.005

Šestan, Marko, Sonja Marinović, Inga Kavazović, Đurđica Cekinović, Stephan Wueest, Tamara Turk Wensveen, Ilija Brizić, et al. "Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity." Immunity 49, no. 1 (2018): 164-177. https://doi.org/10.1016/j.immuni.2018.05.005

Šestan, M., et al. (2018) 'Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity', Immunity, 49(1), pp. 164-177. doi: 10.1016/j.immuni.2018.05.005

Šestan M, Marinović S, Kavazović I, Cekinović Đ, Wueest S, Turk Wensveen T, and sur.. Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity. Immunity [Internet]. 2018 [cited 2024 April 22];49(1):164-177. doi: 10.1016/j.immuni.2018.05.005

M. Šestan, et al., "Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity", Immunity, vol. 49, no. 1, pp. 164-177, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:599545. [Accessed: 22 April 2024]

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Metadata
Title (english)Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity
AuthorMarko Šestan
AuthorSonja Marinović
AuthorInga Kavazović
AuthorĐurđica Cekinović
AuthorStephan Wueest
AuthorTamara Turk Wensveen
AuthorIlija Brizić
AuthorStipan Jonjić
AuthorDaniel Konrad
AuthorFelix M Wensveen
AuthorBojan Polić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Pro-inflammatory cytokines of a T helper-1-signature are known to promote insulin resistance (IR) in obesity, but the physiological role of this mechanism is unclear. It is also unknown whether and how viral infection induces loss of glycemic control in subjects at risk for developing diabetes mellitus type 2 (DM2). We have found in mice and humans that viral infection caused short-term systemic IR. Virally-induced interferon-γ (IFN-γ) directly targeted skeletal muscle to downregulate the insulin receptor but did not cause loss of glycemic control because of a compensatory increase of insulin production. Hyperinsulinemia enhanced antiviral immunity through direct stimulation of CD8+ effector T cell function. In pre-diabetic mice with hepatic IR caused by diet-induced obesity, infection resulted in loss of glycemic control. Thus, upon pathogen encounter, the immune system transiently reduces insulin sensitivity of skeletal muscle to induce hyperinsulinemia and promote antiviral immunity, which derails to glucose intolerance in pre-diabetic obese subjects. . VIDEO ABSTRACT
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionAccepted version
Journal titleImmunity
Numberingvol. 49, no. 1, pp. 164-177, e6
p-ISSN1074-7613
e-ISSN1097-4180
DOIhttps://doi.org/10.1016/j.immuni.2018.05.005
URN:NBNurn:nbn:hr:184:599545
Publication2018
ProjectNumber: N/A
Title (croatian): Centar izvrsnosti za virusnu imunologiju i cjepiva
Title (english): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Acronym: CERVirVac
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZCI
ProjectNumber: IP-2016-06-8027
Title (croatian): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva
Title (english): Rewriting memory; Manipulation of T cell memory to enhance vaccine efficiency
Acronym: T-MEMORY
Leader: Felix Martinus Wensveen
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: IP-2016-06-9306
Title (croatian): Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini
Title (english): Immune mechanisms in development of inflammation and metabolic syndrome in obesity
Acronym: INFLAMETAB
Leader: Bojan Polić
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: KK.011.1.01.0006
Title (english): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: eu
Document URLhttps://doi.org/10.1016/j.immuni.2018.05.005
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2019-11-12 16:26:33