prikaz prve stranice dokumenta Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease
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Scientific paper - Original scientific paper
Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease
Journal of Clinical Medicine, 8 (2019), 11; 1861. https://doi.org/10.3390/jcm8111861
Petrović, Davor; Benzon, Benjamin; Batinić, Marijan; Culić, Srđana; Roganović, Jelena; Markić, Joško

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Petrović, D., Benzon, B., Batinić, M., Culić, S., Roganović, J. & Markić, J. (2019). Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease. Journal of Clinical Medicine, 8. (11). doi: 10.3390/jcm8111861

Petrović, Davor, et al. "Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease." Journal of Clinical Medicine, vol. 8, no. 11, 2019. https://doi.org/10.3390/jcm8111861

Petrović, Davor, Benjamin Benzon, Marijan Batinić, Srđana Culić, Jelena Roganović and Joško Markić. "Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease." Journal of Clinical Medicine 8, no. 11 (2019). https://doi.org/10.3390/jcm8111861

Petrović, D., et al. (2019) 'Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease', Journal of Clinical Medicine, 8(11). doi: 10.3390/jcm8111861

Petrović D, Benzon B, Batinić M, Culić S, Roganović J, Markić J. Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease. Journal of Clinical Medicine [Internet]. 2019 November 03 [cited 2024 April 27];8(11). doi: 10.3390/jcm8111861

D. Petrović, B. Benzon, M. Batinić, S. Culić, J. Roganović and J. Markić, "Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease", Journal of Clinical Medicine, vol. 8, no. 11, November 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:275062. [Accessed: 27 April 2024]

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Metadata
Title (english)Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease
AuthorDavor Petrović
AuthorBenjamin Benzon
AuthorMarijan Batinić
AuthorSrđana Culić
AuthorJelena Roganović
AuthorJoško Markić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pediatrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by isolated thrombocytopenia defined as platelet count in peripheral blood <100 × 109/L. Hypovitaminosis D is very common in children with autoimmune diseases. To analyze whether hypovitaminosis D is associated with the clinical presentation of ITP in children, medical records of 45 pediatric patients with newly diagnosed immune thrombocytopenia in the coastal region of Croatia were evaluated. The severity of bleeding was assessed using two bleeding scores. Children with lower 25-hydroxyvitamin D (25(OH)D) values had higher values of the skin-mucosa-organ-gradation (SMOG) bleeding score and respectively more severe bleeding on diagnosis of ITP. With further analysis of the main domains of that score, we found that patients with a lower 25(OH)D value had more severe bleeding in the skin and organs. When 25(OH)D and ITP Bleeding Scale (IBLS) score were analyzed, a negative correlation was found, but it was not significant. Our findings suggest that hypovitaminosis D influences the severity of the clinical presentation of ITP in children on initial diagnosis of the disease. Therefore, therapy with 25(OH)D could be a new potential option for treatment of ITP. To investigate the connection between 25(OH)D and the incidence and severity of ITP, further studies, especially randomized controlled studies, are needed.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Clinical Medicine
Numberingvol. 8, no. 11, 1861
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm8111861
URN:NBNurn:nbn:hr:184:275062
Publication2019-11-03
Document URLhttps://www.mdpi.com/2077-0383/8/11/1861
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2019-11-07 16:35:55