prikaz prve stranice dokumenta Effect of local anesthesia with lidocaine on perioperative proinflammatory cytokine levels in plasma and cerebrospinal fluid in cerebral aneurysm patients
  Download
PDF 176.21 KB
Scientific paper - Original scientific paper
Effect of local anesthesia with lidocaine on perioperative proinflammatory cytokine levels in plasma and cerebrospinal fluid in cerebral aneurysm patients
Medicine, 98 (2019), 42; 17450. https://doi.org/10.1097/MD.0000000000017450
Matas, Marijana; Sotošek, Vlatka; Kozmar, Ana; Likić, Robert; Sekulić, Ante

Citations:
,
Cite this document

Matas, M., Sotošek, V., Kozmar, A., Likić, R. & Sekulić, A. (2019). Effect of local anesthesia with lidocaine on perioperative proinflammatory cytokine levels in plasma and cerebrospinal fluid in cerebral aneurysm patients. Medicine, 98. (42). doi: 10.1097/MD.0000000000017450

Matas, Marijana, et al. "Effect of local anesthesia with lidocaine on perioperative proinflammatory cytokine levels in plasma and cerebrospinal fluid in cerebral aneurysm patients." Medicine, vol. 98, no. 42, 2019. https://doi.org/10.1097/MD.0000000000017450

Matas, Marijana, Vlatka Sotošek, Ana Kozmar, Robert Likić and Ante Sekulić. "Effect of local anesthesia with lidocaine on perioperative proinflammatory cytokine levels in plasma and cerebrospinal fluid in cerebral aneurysm patients." Medicine 98, no. 42 (2019). https://doi.org/10.1097/MD.0000000000017450

Matas, M., et al. (2019) 'Effect of local anesthesia with lidocaine on perioperative proinflammatory cytokine levels in plasma and cerebrospinal fluid in cerebral aneurysm patients', Medicine, 98(42). doi: 10.1097/MD.0000000000017450

Matas M, Sotošek V, Kozmar A, Likić R, Sekulić A. Effect of local anesthesia with lidocaine on perioperative proinflammatory cytokine levels in plasma and cerebrospinal fluid in cerebral aneurysm patients. Medicine [Internet]. 2019 October [cited 2025 April 01];98(42). doi: 10.1097/MD.0000000000017450

M. Matas, V. Sotošek, A. Kozmar, R. Likić and A. Sekulić, "Effect of local anesthesia with lidocaine on perioperative proinflammatory cytokine levels in plasma and cerebrospinal fluid in cerebral aneurysm patients", Medicine, vol. 98, no. 42, October 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:813559. [Accessed: 01 April 2025]

Please login to the repository to save this object to your list.
Metadata
Title (english)Effect of local anesthesia with lidocaine on perioperative proinflammatory cytokine levels in plasma and cerebrospinal fluid in cerebral aneurysm patients
AuthorMarijana Matas
AuthorVlatka Sotošek
AuthorAna Kozmar
AuthorRobert Likić
AuthorAnte Sekulić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Cerebral aneurysm surgery has significant mortality and morbidity rate. Inflammation plays a key role in the pathogenesis of intracranial aneurysms, their rupture, subarachnoid hemorrhage and neurologic complications. Proinflammatory cytokine level in blood and cerebrospinal fluid (CSF) is an indicator of inflammatory response. Cytokines contribute to secondary brain injury and can worsen the outcome of the treatment. Lidocaine is local anesthetic that can be applied in neurosurgery as regional... More anesthesia of the scalp and as topical anesthesia of the throat before direct laryngoscopy and endotracheal intubation. Besides analgesic, lidocaine has systemic anti-inflammatory and neuroprotective effect.Primary aim of this trial is to determine the influence of local anesthesia with lidocaine on the perioperative levels of pro-inflammatory cytokines interleukin-1β, interleukin-6, and tumor necrosis factor-α in plasma and CSF in cerebral aneurysm patients. METHODS: We will conduct prospective randomized clinical trial among patients undergoing craniotomy and cerebral aneurysm clipping surgery in general anesthesia. Patients included in the trial will be randomly assigned to the lidocaine group (Group L) or to the control group (Group C). Patients in Group L, following general anesthesia induction, will receive topical anesthesia of the throat before endotracheal intubation and also regional anesthesia of the scalp before Mayfield frame placement, both done with lidocaine. Patients in Group C will have general anesthesia only without any lidocaine administration. The primary outcomes are concentrations of cytokines interleukin-1β, interleukin-6 and tumor necrosis factor-α in plasma and CSF, measured at specific timepoints perioperatively. Secondary outcome is incidence of major neurological and infectious complications, as well as treatment outcome in both groups. DISCUSSION: Results of the trial could provide insight into influence of lidocaine on local and systemic inflammatory response in cerebrovascular surgery, and might improve future anesthesia practice and treatment outcome. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedicine
Numberingvol. 98, no. 42, 17450
p-ISSN0025-7974
DOIhttps://doi.org/10.1097/MD.0000000000017450
URN:NBNurn:nbn:hr:184:813559
Publication2019-10
Document URLhttps://journals.lww.com/md-journal/Fulltext/2019/10180/Effect_of_local_anesthesia_with_lidocaine_on.22.aspx
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2019-10-21 20:49:36
accessibility

closeAccessibilityrefresh

If you wish to permanently save changes, click on Save, if not - your settings will be reset when you restart the browser.