prikaz prve stranice dokumenta Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes
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Scientific paper - Original scientific paper
Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes
Oxidative Medicine and Cellular Longevity, 2016 (2016); 1-13. https://doi.org/10.1155/2016/9191407
Marinić, Jelena; Broznić, Dalibor; Milin, Čedomila

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Marinić, J., Broznić, D. & Milin, Č. (2016). Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes. Oxidative Medicine and Cellular Longevity, 2016., 1-13. doi: 10.1155/2016/9191407

Marinić, Jelena, et al. "Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes." Oxidative Medicine and Cellular Longevity, vol. 2016, 2016, pp. 1-13. https://doi.org/10.1155/2016/9191407

Marinić, Jelena, Dalibor Broznić and Čedomila Milin. "Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes." Oxidative Medicine and Cellular Longevity 2016 (2016): 1-13. https://doi.org/10.1155/2016/9191407

Marinić, J., Broznić, D. and Milin, Č. (2016) 'Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes', Oxidative Medicine and Cellular Longevity, 2016, pp. 1-13. doi: 10.1155/2016/9191407

Marinić J, Broznić D, Milin Č. Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes. Oxidative Medicine and Cellular Longevity [Internet]. 2016 [cited 2024 May 06];2016:1-13. doi: 10.1155/2016/9191407

J. Marinić, D. Broznić and Č. Milin, "Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes", Oxidative Medicine and Cellular Longevity, vol. 2016, pp. 1-13, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:696066. [Accessed: 06 May 2024]

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Metadata
Title (english)Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes
AuthorJelena Marinić
AuthorDalibor Broznić
AuthorČedomila Milin
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Medical Biochemistry
Abstract (english)
Polyphenols can act as oxidants in some conditions, inducing redox-sensitive genes. We investigated the effect of preexposure to the olive oil polyphenols extract (PFE) on time-dependent changes in the hepatic oxidative state in a model of liver regeneration—a process in which oxidative stress associated with the metabolic overload accounts for the early events that contribute to the onset of liver self-repair. Liver regeneration was induced by one-third hepatectomy in mice. Prior to hepatectomy, mice were intraperitoneally given either PFE (50 mg/kg body weight) or saline for seven consecutive days, while respective controls received vehicle alone. Redox state-regulating enzymes and thiol proteins along with the mRNA levels of Nrf2 gene and its targets -glutamylcysteine synthetase and heme oxygenase-1 were determined at different time intervals after hepatectomy. The liver mass restoration was calculated to assess hepatic regeneration. The resulting data demonstrate the effectiveness of preexposure to PFE in stimulating liver regeneration in a model of a small tissue loss which may be ascribed to the transient increase in oxidant load during the first hours after hepatectomy and associated induction of stress response gene-profiles under the control of Nrf2.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleOxidative Medicine and Cellular Longevity
Numberingvol. 2016, pp. 1-13
p-ISSN1942-0900
e-ISSN1942-0994
DOIhttps://doi.org/10.1155/2016/9191407
URN:NBNurn:nbn:hr:184:696066
Publication2016
Document URLhttp://www.hindawi.com/journals/omcl/2016/9191407/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2019-04-02 09:09:36