prikaz prve stranice dokumenta Etiologija i patogeneza sustavnih autoimunih bolesti s manifestacijama u usnoj šupljini
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master's thesis
Etiologija i patogeneza sustavnih autoimunih bolesti s manifestacijama u usnoj šupljini
prikaz slučaja
2013. urn:nbn:hr:184:150000
Zarubica, Milijana
University of Rijeka
Faculty of Medicine
Department of Oral Medicine and Periodontology

Cite this document

Zarubica, M. (2013). Etiologija i patogeneza sustavnih autoimunih bolesti s manifestacijama u usnoj šupljini : prikaz slučaja (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:150000

Zarubica, Milijana. "Etiologija i patogeneza sustavnih autoimunih bolesti s manifestacijama u usnoj šupljini : prikaz slučaja." Master's thesis, University of Rijeka, Faculty of Medicine, 2013. https://urn.nsk.hr/urn:nbn:hr:184:150000

Zarubica, Milijana. "Etiologija i patogeneza sustavnih autoimunih bolesti s manifestacijama u usnoj šupljini : prikaz slučaja." Master's thesis, University of Rijeka, Faculty of Medicine, 2013. https://urn.nsk.hr/urn:nbn:hr:184:150000

Zarubica, M. (2013). 'Etiologija i patogeneza sustavnih autoimunih bolesti s manifestacijama u usnoj šupljini : prikaz slučaja', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 24 December 2024, https://urn.nsk.hr/urn:nbn:hr:184:150000

Zarubica M. Etiologija i patogeneza sustavnih autoimunih bolesti s manifestacijama u usnoj šupljini : prikaz slučaja [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2013 [cited 2024 December 24] Available at: https://urn.nsk.hr/urn:nbn:hr:184:150000

M. Zarubica, "Etiologija i patogeneza sustavnih autoimunih bolesti s manifestacijama u usnoj šupljini : prikaz slučaja", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:184:150000

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Metadata
TitleEtiologija i patogeneza sustavnih autoimunih bolesti s manifestacijama u usnoj šupljini : prikaz slučaja
Title (english)Etiology and pathogenesis of systemic autoimmune disease with oral manifestations : a case report
AuthorMilijana Zarubica
MentorSonja Pezelj-Ribarić (mentor)
Committee memberSonja Pezelj-Ribarić
Committee memberIrena Glažar
Committee memberIvana Brekalo-Pršo
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Oral Medicine and Periodontology)
Rijeka
Defense date and country2013, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Oral Medicine
Abstract
U sustavne autoimune bolesti spadaju i vezikulobulozne bolesti. Vezikulobulozne bolesti zajednički je naziv za niz bolesti koje zahvaćaju kožu i sluznicu, a obilježava ih stvaranje bula i vezikula. Bolesti su okarakerizirane vezanjem autoantitijela na različite adhezijske molekule epidermisa i zone bazalne membrane što rezultira gubitkom adhezije među stanicama, a klinički se očituje kao erozivne i bulozne promjene. Bolesti se manifestiraju sa sličnim simptomima pa ih je vrlo teško diferencijalno dijagnostički odijeliti. Točna dijagnostika temelji se na anamnezi, kliničkom pregledu te patohistološkim nalazima i imunološkoj dijagnostici. Pemphigus i pemfigoid imaju zajednički prefiks, ali su to dvije različite bolesti. Teško ih je odijeliti samo kliničkim pregledom stoga je potrebna laboratorijska dijagnostika. Izravna i neizravna imunofluorescencija standard su u dijagnostici. Rano prepoznavanje simptoma bolesti, pravilna dijagnostika i terapija ključ su za liječenje ovih bolesti koje su davno prepoznate, a još uvijek nije otkriven točan uzrok nastanka bolesti.
Abstract (english)
Vesiculobullous skin diseases represent a group of systemic autoimmune diseases. Vesiculobullous skin diseases is a common term for a variety of lesions affecting skin and mucous membranes resulting in blister formation and extensive erosions. Diseases are characterised by binding of circulating autoantibodies to adhesions molecules of the epidermis and the basement membrane zone. It results with the loss of adhesion between cells causing blisters and erosions. Diseases manifest with a similar symptoms so it is very hard to establish a correct diagnosis. Making the diagnosis of autoimmune bullous skin diseases is based on anamnesis, clinical aspects, histopathological examinations and immunofluorescence. Pemphigus and pemphigoid have the same prefix, but in base they are completely two different diseases. One of this diseases does not ruled out the other so it is very important to make laboratory diagnosis. Direct and indirect immunofluorescence represent a gold standard in diagnosis of those two diseases. Early management of the disease, correct diagnosis and a proper therapy leads to healing in this diseases which are very old, but with the strange causes.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:150000
Study programmeTitle: Dental Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2016-03-04 12:50:32