Skeletal class III malocclusion are often presented as a combination of insufficient growth of the upper jaw and excessive growth of the lower jaw. Early treatment of skeletal class III malocclusion is applied during the early mixed dentition, when circummaxillary sutures still have not completed their ossification and anterior movement of the maxilla can be achieved. The aim of this research was to determine the effectiveness of the early treatmnet of skeletal class III malocclusion with maxillary expansion and face mask therapy. Prospective research has been performed. A total of 8 patients with skeletal class III malocclusion were treated with maxillary expansion and face mask therapy during the period of early mixed dentition. Face mask therapy lasted 12 months. Effectiveness of the early treatmnet was evaluated by comparison of the values of cephalometric variables measured before and after therapy. A total of 21 cephalometric variables concering skeletal and dentoalveolar structures were measured. Statistic analysis were performed using Wilcoxon test, with significance set at a P value < 0,05. Therapy resulted with significant increase of the angle of maxillary protrusion (P=0,036), significant increase of the angle of skeletal class (P=0,025) and significant increase of over-jet (P=0,018). Changes of the values of other skeletal and dentoalveolar variables were not statistically significant. Tendencies toward the increase of the vertical dimension of the face, protrusion of the upper incisors, retrusion of the lower incisors and toward the increase of over-bite were observed. Early treatment of skeletal class III malocclusion with maxillary expansion and face mask therapy produced significant skeletal anterior translation of maxilla with less noticed dentoalveolar compensations and increase of the vertical facial dimension.