Tumor Necrosis Factor-alpha-308 Gene Polymorphism in Croatian and Slovenian Multiple Sclerosis Patients

Ristić, Smiljana; Lovrečić, Luca; Starčević-Čizmarević, Nada; Brajenović-Milić, Bojana; Šega Jazbec, Saša; Sepčić, Juraj; Kapović, Miljenko; Peterlin, Borut

Scientific paper - Original scientific paper

Tumor Necrosis Factor-alpha-308 Gene Polymorphism in Croatian and Slovenian Multiple Sclerosis Patients

European Neurology, 57 (2007), 4; 203-207. urn:nbn:hr:184:786338

Ristić, Smiljana; Lovrečić, Luca; Starčević-Čizmarević, Nada; Brajenović-Milić, Bojana; Šega Jazbec, Saša; Sepčić, Juraj; Kapović, Miljenko; Peterlin, Borut

Cite this document

APA 6th Edition

Ristić, S., Lovrečić, L., Starčević Čizmarević, N., Brajenović Milić, B., Šega Jazbec, S., Sepčić, J. ... Peterlin, B. (2007). Tumor Necrosis Factor-alpha-308 Gene Polymorphism in Croatian and Slovenian Multiple Sclerosis Patients. European Neurology, 57. (4), 203-207. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:786338

MLA 8th Edition

Ristić, Smiljana, et al. "Tumor Necrosis Factor-alpha-308 Gene Polymorphism in Croatian and Slovenian Multiple Sclerosis Patients." European Neurology, vol. 57, no. 4, 2007, pp. 203-207. https://urn.nsk.hr/urn:nbn:hr:184:786338

Chicago 17th Edition

Ristić, Smiljana, Luca Lovrečić, Nada Starčević Čizmarević, Bojana Brajenović Milić, Saša Šega Jazbec, Juraj Sepčić, Miljenko Kapović and Borut Peterlin. "Tumor Necrosis Factor-alpha-308 Gene Polymorphism in Croatian and Slovenian Multiple Sclerosis Patients." European Neurology 57, no. 4 (2007): 203-207. https://urn.nsk.hr/urn:nbn:hr:184:786338

Harvard

Ristić, S., et al. (2007) 'Tumor Necrosis Factor-alpha-308 Gene Polymorphism in Croatian and Slovenian Multiple Sclerosis Patients', European Neurology, 57(4), pp. 203-207. Available at: https://urn.nsk.hr/urn:nbn:hr:184:786338 (Accessed 25 April 2024)

Vancouver

Ristić S, Lovrečić L, Starčević Čizmarević N, Brajenović Milić B, Šega Jazbec S, Sepčić J, and sur.. Tumor Necrosis Factor-alpha-308 Gene Polymorphism in Croatian and Slovenian Multiple Sclerosis Patients. European Neurology [Internet]. 2007 [cited 2024 April 25];57(4):203-207. Available at: https://urn.nsk.hr/urn:nbn:hr:184:786338

IEEE

S. Ristić, et al., "Tumor Necrosis Factor-alpha-308 Gene Polymorphism in Croatian and Slovenian Multiple Sclerosis Patients", European Neurology, vol. 57, no. 4, pp. 203-207, 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:786338. [Accessed: 25 April 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:184:786338

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Metadata

Title (english)	Tumor Necrosis Factor-alpha-308 Gene Polymorphism in Croatian and Slovenian Multiple Sclerosis Patients
Author	Smiljana Ristić MBZ: 142283
Author	Luca Lovrečić
Author	Nada Starčević-Čizmarević
Author	Bojana Brajenović-Milić
Author	Saša Šega Jazbec
Author	Juraj Sepčić
Author	Miljenko Kapović
Author	Borut Peterlin
Author's institution	University of Rijeka Faculty of Medicine (Department of Biology and Medical Genetics)
Author's institution	University of Rijeka Faculty of Medicine (Department of Neurology)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences
Abstract (english)	Previous findings regarding the role of TNF-a-308 gene polymorphism in multiple sclerosis (MS) are contradictory.This study's aim was to investigate the possible influence of TNF-a-308 polymorphism on MS susceptibility and MS disease process in a Croatian and Slovenian population. Genotyping was performed in 338 patients and 460 healthy controls. The TNF2 allele was present in 123 (26.8%) of healthy controls versus 67 (19.9%) of MS patients (p=0.023, odds ratio=0.68, 95% confidence interval=0.48-0.95), suggesting that carriage of the TNF2 allele might decrease MS risk. The difference of TNF2-allele carrier frequency between patients and controls was identified in relapsing-remitting (RR) MS group.There was no association between TNF2-allele carrier status and age at disease onset or disease progression. Our results suggest that in the study populations the TNF-a-308 polymorphism may play a role in MS susceptibility.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review - international
Publication version	Published version
Journal title	European Neurology
Numbering	vol. 57, no. 4, pp. 203-207
p-ISSN	0014-3022
URN:NBN	urn:nbn:hr:184:786338
Publication	2007
Project	Number: 062-1962766-0470 Title (croatian): Genetička analiza multiple skleroze Leader: Smiljana Ristić Jurisdiction: Croatia Funding stream: ZP
Document URL	http://bib.irb.hr/318947
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2019-03-05 11:27:07