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Scientific paper - Review paper
Uloga gastrointestinalnih peptida u patogenezi i liječenju pretilosti
Medicina Fluminensis : Medicina Fluminensis, 55 (2019), 1; 24-31. https://doi.org/10.21860/medflum2019_216319
Poropat, Nina; Jurišić Eržen, Dubravka

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Poropat, N. & Jurišić Eržen, D. (2019). Uloga gastrointestinalnih peptida u patogenezi i liječenju pretilosti. Medicina Fluminensis : Medicina Fluminensis, 55. (1), 24-31. doi: 10.21860/medflum2019_216319

Poropat, Nina and Dubravka Jurišić Eržen. "Uloga gastrointestinalnih peptida u patogenezi i liječenju pretilosti." Medicina Fluminensis : Medicina Fluminensis, vol. 55, no. 1, 2019, pp. 24-31. https://doi.org/10.21860/medflum2019_216319

Poropat, Nina and Dubravka Jurišić Eržen. "Uloga gastrointestinalnih peptida u patogenezi i liječenju pretilosti." Medicina Fluminensis : Medicina Fluminensis 55, no. 1 (2019): 24-31. https://doi.org/10.21860/medflum2019_216319

Poropat, N. and Jurišić Eržen, D. (2019) 'Uloga gastrointestinalnih peptida u patogenezi i liječenju pretilosti', Medicina Fluminensis : Medicina Fluminensis, 55(1), pp. 24-31. doi: 10.21860/medflum2019_216319

Poropat N, Jurišić Eržen D. Uloga gastrointestinalnih peptida u patogenezi i liječenju pretilosti. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2019 March 01 [cited 2024 May 12];55(1):24-31. doi: 10.21860/medflum2019_216319

N. Poropat and D. Jurišić Eržen, "Uloga gastrointestinalnih peptida u patogenezi i liječenju pretilosti", Medicina Fluminensis : Medicina Fluminensis, vol. 55, no. 1, pp. 24-31, March 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:109136. [Accessed: 12 May 2024]

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Metadata
Title (croatian)Uloga gastrointestinalnih peptida u patogenezi i liječenju pretilosti
Title (english)The role of gastrointestinal peptides in the pathogenesis and treatment of obesity
AuthorNina Poropat
AuthorDubravka Jurišić Eržen
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (croatian)
Pretilost predstavlja jedan od najvećih zdravstveno-ekonomskih i socijalnih problema današnjice te se sve veća učestalost pretilosti povezuje s porastom incidencije i pobola niza drugih bolesti, prije svega šećerne bolesti, kardiovaskularnih i cerebrovaskularnih oboljenja te malignih bolesti. U održavanju ravnoteže unosa i potrošnje energije najvažniju regulatornu ulogu ima središnji živčani sustav, odnosno osovina mozak-crijevo, koja se temelji na funkciji niza gastrointestinalnih peptidnih hormona. Djelovanje navedenih peptida izrazito je raznoliko i ovisi o nizu čimbenika, posebno vrsti i količini hrane, energetskom stanju organizma te pratećim bolestima i metaboličkim poremećajima. Djelovanje ovih hormona usko je povezano s endokrinom funkcijom gušterače, lučenjem inzulina i regulacijom glikemije, što ujedno ukazuje i na jasnu povezanost pretilosti i šećerne bolesti. Velik napredak na području razvoja i primjene novih antidijabetika u klasi peptidnih hormona, odnosno inkretina, te utvrđivanje njihovih dodatnih svojstava u smislu redukcije tjelesne težine, otvorili su tijekom posljednjih godina čitavo novo područje istraživanja farmakoterapije pretilosti. Obećavajuće rezultate prije svega pružaju nove mogućnosti kombinacije više lijekova, čime se ponovno stvara mogućnost razvoja adekvatne farmakoterapije kao alternative kirurškom pristupu liječenju pretilosti.
Abstract (english)
Obesity is one of the biggest health-economic and social problems of today and its increasing incidence is aassociated with an increasing incidence and morbiditiy of a number of other diseases, primarily diabetes, cardiovascular and cerebrovascular diseases, and malignant diseases as well. The central nervous system, that is the brain-gut axis has the central role in maintaining the balance of input and energy consumption, which is regulated by a variety of gastrointestinal peptide hormones. The role and action of these peptides is highly variable and depends on a number of factors, especially the type and the amount of food, energy status of the organism, and the accompanying diseases and metabolic disorders. They are closely connected with the pancreatic endocrine function, insuline secretion and regulation of glycaemia, which also shows a clear link between obesity and diabetes. A great progress in the development and appication of new antidiabetics in the class of peptide hormones or incretins, and their additional weight-loss properties have opened a whole new field of the pharmacotherapy researches in the treatment of obesity. The promising results are provided by the new drug combinations, which leads to new possibilities of pharmacotherapy as an alternative to the surgical treatment of obesity.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 55, no. 1, pp. 24-31
p-ISSN1847-6864
e-ISSN1848-1868
DOIhttps://doi.org/10.21860/medflum2019_216319
URN:NBNurn:nbn:hr:184:109136
Publication2019-03-01
Document URLhttps://hrcak.srce.hr/216319
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 3.0 Unported (CC BY 3.0) icon
Created on2019-03-01 10:46:46