Introduction: Numerous studies have confirmed that children with idiopathic epilepsy (IE) are at increased risk for adjustment problems such as internalized disorders, reduced self-concept and lower academic achievement compared to healthy children as well as children with other chronic diseases. However, correlates of children’s adjustment are still vague especially regarding to epilepsy/seizures and psychological adaptation. Objectives: the aim of this study was to examine the predictors of adaptation of children with IE within the Wallander-Varni model of risk and resilience factors for adaptation to the disease and assessing whether children with IE differ according to the basic division due to the type of seizures (focal and generalized) in risk, resiliance factors and adaptations. Subjects and Methods: A total of 128 children (9 to 16.10 years) diagnosed with IE, including 71 with focal and 57 with generalized seizures, were included in the study. The research process was based on demographic data, characteristics of illness and treatment, school success, intellectual ability, and application of a child self-assessment questionnaires (stress scale, stigma, coping strategy, family relationship quality, social support and anxiety, depression, anger, disruptive behavior and self-concept. Results: Both risk and resilience factors contribute significantly to the adjustment. Significant predictors of weaker adaptations were focal type of seizures, higher levels of stigma, stress and stress sensitivity as well as longer duration of illness. A consistent profile of intellectual functioning, family quality, relationship with mother and father were predictors of better adjustment in the aspect of emotional functioning, and the higher level of intelligence the better school achievement. According to the type of epilepsy, the established differences between groups indicate that children with focal seizures are more sensitive to stress, have a lower working memory, and more frequent uneven intellectual profile, as well as a poorer adjustment to higher levels of emotional disturbance symptoms. Conclusion: It is confirmed for the first time that Walander-Varni model is useful to establish predictors of adaptation and contribute to the explanation of individual differences and variability of psychological adaptation in children with IE. That provide scientifically proof basis for the development of aimed prevention and intervention programs.