prikaz prve stranice dokumenta Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection
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Scientific paper - Original scientific paper
Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection
The Journal of Experimental Medicine, 188 (1998), 6; 1047-1054. https://doi.org/10.1084/jem.188.6.1047
Polić, Bojan; Hengel, Hartmut; Krmpotić, Astrid; Trgovcich, Joanne; Pavić, Ivica; Lučin, Pero; Jonjić, Stipan; Koszinowski, Ulrich H.

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Polić, B., Hengel, H., Krmpotić, A., Trgovcich, J., Pavić, I., Lučin, P. ... Koszinowski, U. H. (1998). Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection. The Journal of Experimental Medicine, 188. (6), 1047-1054. doi: 10.1084/jem.188.6.1047

Polić, Bojan, et al. "Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection." The Journal of Experimental Medicine, vol. 188, no. 6, 1998, pp. 1047-1054. https://doi.org/10.1084/jem.188.6.1047

Polić, Bojan, Hartmut Hengel, Astrid Krmpotić, Joanne Trgovcich, Ivica Pavić, Pero Lučin, Stipan Jonjić and Ulrich H. Koszinowski. "Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection." The Journal of Experimental Medicine 188, no. 6 (1998): 1047-1054. https://doi.org/10.1084/jem.188.6.1047

Polić, B., et al. (1998) 'Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection', The Journal of Experimental Medicine, 188(6), pp. 1047-1054. doi: 10.1084/jem.188.6.1047

Polić B, Hengel H, Krmpotić A, Trgovcich J, Pavić I, Lučin P, and sur.. Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection. The Journal of Experimental Medicine [Internet]. 1998 September 21 [cited 2025 January 23];188(6):1047-1054. doi: 10.1084/jem.188.6.1047

B. Polić, et al., "Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection", The Journal of Experimental Medicine, vol. 188, no. 6, pp. 1047-1054, September 1998. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:185952. [Accessed: 23 January 2025]

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Metadata
Title (english)Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection
AuthorBojan Polić
AuthorHartmut Hengel
AuthorAstrid Krmpotić
AuthorJoanne Trgovcich
AuthorIvica Pavić
AuthorPero Lučin
AuthorStipan Jonjić
AuthorUlrich H. Koszinowski
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Reactivation from latent cytomegalovirus (CMV) infection is often associated with conditions of immunosuppression and can result in fatal disease. Whether the maintenance of systemic CMV latency is mainly governed by factors of the infected cell or by immune control functions is unknown. Likewise, the putative immune control mechanisms which could prevent the induction and spread of recurrent CMV infection are not clearly identified. We took advantage of latently infected B cell-deficient mice and a sensitive method for virus detection to study CMV reactivation after ablation of lymphocyte subsets. A crucial role of both T lymphocytes and natural killer (NK) cells was demonstrated. Within 5 d after depletion of lymphocytes, productive infection occurred in 50% of mice, and 14 d later 100% of mice exhibited recurrent infection. A hierarchy of immune control functions of CD8(+), NK, and CD4(+) cells was established. Reactivation was rare if only one of the lymphocyte subsets was depleted, but was evident after removal of a further subset, indicating a functional redundancy of control mechanisms. The salivary glands were identified as the site of most rapid virus shedding, followed by the detection of recurrent virus in the lungs, and eventually in the spleen. Our findings document a previously unknown propensity of latent CMV genomes to enter productive infection immediately and with a high frequency after immune cell depletion. The data indicate that only the sustained cellular immune control prevents CMV replication and restricts the viral genome to a systemic state of latency.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleThe Journal of Experimental Medicine
Numberingvol. 188, no. 6, pp. 1047-1054
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.188.6.1047
URN:NBNurn:nbn:hr:184:185952
Publication1998-09-21
Publication1998-09-21
Document URLhttp://www.jem.org/lookup/doi/10.1084/jem.188.6.1047
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2018-12-12 18:15:10