prikaz prve stranice dokumenta Escape of Mutant Double-Stranded DNA Virus from Innate Immune Control
  Download
PDF 230.05 KB
Scientific paper - Original scientific paper
Escape of Mutant Double-Stranded DNA Virus from Innate Immune Control
Immunity, 20 (2004), 6; 747-756. https://doi.org/10.1016/j.immuni.2004.05.006
French, Anthony R; Pingel, Jeanette T; Wagner, Markus; Bubić, Ivan; Yang, Liping; Kim, Sungjin; Koszinowski, Ulrich; Jonjić, Stipan; Yokoyama, Wayne M

Cite this document

French, A. R., Pingel, J. T., Wagner, M., Bubić, I., Yang, L., Kim, S. ... Yokoyama, W. M. (2004). Escape of Mutant Double-Stranded DNA Virus from Innate Immune Control. Immunity, 20. (6), 747-756. doi: 10.1016/j.immuni.2004.05.006

French, Anthony R, et al. "Escape of Mutant Double-Stranded DNA Virus from Innate Immune Control." Immunity, vol. 20, no. 6, 2004, pp. 747-756. https://doi.org/10.1016/j.immuni.2004.05.006

French, Anthony R, Jeanette T Pingel, Markus Wagner, Ivan Bubić, Liping Yang, Sungjin Kim, Ulrich Koszinowski, Stipan Jonjić and Wayne M Yokoyama. "Escape of Mutant Double-Stranded DNA Virus from Innate Immune Control." Immunity 20, no. 6 (2004): 747-756. https://doi.org/10.1016/j.immuni.2004.05.006

French, A. R., et al. (2004) 'Escape of Mutant Double-Stranded DNA Virus from Innate Immune Control', Immunity, 20(6), pp. 747-756. doi: 10.1016/j.immuni.2004.05.006

French AR, Pingel JT, Wagner M, Bubić I, Yang L, Kim S, and sur.. Escape of Mutant Double-Stranded DNA Virus from Innate Immune Control. Immunity [Internet]. 2004 June [cited 2024 October 31];20(6):747-756. doi: 10.1016/j.immuni.2004.05.006

A. R. French, et al., "Escape of Mutant Double-Stranded DNA Virus from Innate Immune Control", Immunity, vol. 20, no. 6, pp. 747-756, June 2004. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:150426. [Accessed: 31 October 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Escape of Mutant Double-Stranded DNA Virus from Innate Immune Control
AuthorAnthony R French
AuthorJeanette T Pingel
AuthorMarkus Wagner
AuthorIvan Bubić
AuthorLiping Yang
AuthorSungjin Kim
AuthorUlrich Koszinowski
AuthorStipan Jonjić
AuthorWayne M Yokoyama
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
As innate immune system components, natural killer (NK) cells respond rapidly to infections and effectively control replication of pathogens, including murine cytomegalovirus (MCMV), a double-stranded DNA beta-herpesvirus. In the absence of NK cell control, MCMV infection results in early mortality due to uncontrolled viral replication. However, here we show that even in the face of initial NK cell control, there is late recrudescence of disease and mortality in immunodeficient mice due to the outgrowth of MCMV mutants that escape recognition by innate NK cells. These data suggest that viral infections in certain clinical settings also may be due to viral escape from innate immunity.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleImmunity
Numberingvol. 20, no. 6, pp. 747-756
p-ISSN1074-7613
DOIhttps://doi.org/10.1016/j.immuni.2004.05.006
URN:NBNurn:nbn:hr:184:150426
Publication2004-06
Document URLhttp://linkinghub.elsevier.com/retrieve/pii/S1074761304001384
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-22 21:22:29