The definition of sepsis is a subject of continuous change and for that reason the clinical criteria for diagnosis is not precise enough. It is very important to recognize it at an early stage because it is a life-threatening condition that leads to organ damage and possible expansion to septic shock and death. Reckoning on physiological changes in pregnancy and puerperia, the criteria for diagnosis of sepsis in obstetrics are prone to changes and as such they should be identified and reacted to, promptly. In the most patients, following symptoms can be found: shaking chills, sweating, vomiting, general weakness, syncope, headache, dyspnea. Already in patients with such symptomatology sepsis should be suspected and physician should seek for source of infection. Furthermore, it is necessary to carefully observe pregnant women with risk factors such as: obesity, immune disorders, type 2 diabetes mellitus, increased vaginal discharge, etc. Patients with a predisposition to develop infection should be monitored and the importance of regular controls and proper hygiene should be carefully explained to them. Outcome of the sepsis can be influenced with prompt application of therapeutic procedures such as adequate hydration, antibiotic therapy, elimination of site of infection. It is considered that every hour of delayed therapy reduces the likelihood of survival. Beside the time, one of the key factors is team work that involves anesthesiologists, obstetricians, intensive medicine care specialists and, if necessary, other specialists such as a surgeon. The holistic approach to patients will significantly contribute in reducing the incidence and mortality in sepsis.