Palliative care is health, psychological, social and spiritual care with the aim of providing necessary care to patients with incurable disease. Typical palliative patient suffer from a whole series of comorbidities, which together with frequent hospitalizations and complications of health problems, makes him extremely challenging patient. The main aim of our research is the analysis of discharge letters of palliative patients and to prepare checklists that should form the basis of the ideal discharge letter, which should improve the communication between specialists in hospital and primary care physician. In palliative care patients, due to a large number of health problems, polypharmacy is often present, which increases the risk of drug interaction and consequently the unwanted side effects. Furthermore, since the underlying disease cannot be treated anymore in terminally ill patients, symptomatic therapy is extremely important in order to maintain a satisfactory quality of life. In spite of the large portion of oncologic patients in palliative care who most probably experience severe pain, strong opioids are rarely prescribed, leading to unsatisfactory control of the symptoms. In addition, the term "analgesics as needed" and prescribing pharmacotherapy as "past" or "symptomatic therapy" should be avoided in a discharge letter because it gives inaccurate information and increases the possibility of making a mistake and to impact negatively on the quality of life of a patient. The most commonly prescribed pharmacotherapy are cardiovascular agents that do not relieve the symptoms, but are part of chronic therapy for comorbid conditions, primarily chronic heart failure. In conclusion, due to the care complexity of palliative patients, the establishment of the discharge letters structure and the proposed checklists are necessary for good communication between doctors and optimum patient care.