prikaz prve stranice dokumenta Interlaboratory concordance in HER-2 positive breast cancer
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Professional paper - Professional paper
Interlaboratory concordance in HER-2 positive breast cancer
Acta clinica Croatica, 54 (2015), 4; 479-485. urn:nbn:hr:184:926373
Jonjić, Nives; Mustać, Elvira; Tomić, Snježana; Razumović Jakić, Jasminka; Šarčević, Božena; Blažičević, Valerija; Labinac Peteh, Loredana; Švagelj, Dražen; Kopjar, Andrina; Šikić Lisica, Nataša; Vrbičić, Branka; Borić, Igor

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Jonjić, N., Mustać, E., Tomić, S., Razumović Jakić, J., Šarčević, B., Blažičević, V. ... Borić, I. (2015). Interlaboratory concordance in HER-2 positive breast cancer. Acta clinica Croatica, 54. (4), 479-485. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:926373

Jonjić, Nives, et al. "Interlaboratory concordance in HER-2 positive breast cancer." Acta clinica Croatica, vol. 54, no. 4, 2015, pp. 479-485. https://urn.nsk.hr/urn:nbn:hr:184:926373

Jonjić, Nives, Elvira Mustać, Snježana Tomić, Jasminka Razumović Jakić, Božena Šarčević, Valerija Blažičević, Loredana Labinac Peteh, et al. "Interlaboratory concordance in HER-2 positive breast cancer." Acta clinica Croatica 54, no. 4 (2015): 479-485. https://urn.nsk.hr/urn:nbn:hr:184:926373

Jonjić, N., et al. (2015) 'Interlaboratory concordance in HER-2 positive breast cancer', Acta clinica Croatica, 54(4), pp. 479-485. Available at: https://urn.nsk.hr/urn:nbn:hr:184:926373 (Accessed 14 November 2024)

Jonjić N, Mustać E, Tomić S, Razumović Jakić J, Šarčević B, Blažičević V, and sur.. Interlaboratory concordance in HER-2 positive breast cancer. Acta clinica Croatica [Internet]. 2015 [cited 2024 November 14];54(4):479-485. Available at: https://urn.nsk.hr/urn:nbn:hr:184:926373

N. Jonjić, et al., "Interlaboratory concordance in HER-2 positive breast cancer", Acta clinica Croatica, vol. 54, no. 4, pp. 479-485, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:926373. [Accessed: 14 November 2024]

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Metadata
Title (english)Interlaboratory concordance in HER-2 positive breast cancer
AuthorNives Jonjić
AuthorElvira Mustać
AuthorSnježana Tomić
AuthorJasminka Razumović Jakić
AuthorBožena Šarčević
MBZ: 87995
AuthorValerija Blažičević
MBZ: 232314
AuthorLoredana Labinac Peteh
MBZ: 304022
AuthorDražen Švagelj
MBZ: 224894
AuthorAndrina Kopjar
AuthorNataša Šikić Lisica
AuthorBranka Vrbičić
AuthorIgor Borić
MBZ: 253942
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
Accurate assessment of HER-2 status is essential for identifying patients who will benefit from HER-2 targeted therapy. The aim of the present study was to show results on the concordance between local and central laboratory testing results in HER-2 positive breast cancer patients. In cases with discordant findings, the immunohistochemical (IHC) and/or in situ hybridization (FISH/SISH) analysis was performed in central laboratories. A total of 104 out of 143 (72.72%) breast carcinomas cases were HER-2 positive (score 3+), while nearly 14% of tumors (20/43) showed weak (score 2+) and 12% (19/143) negative IHC staining (score 0 and 1+). After repeated IHC and ISH, 88% (126/143) were classified as HER-2 positive and 12% (17/143) as HER-2 negative cases. The results obtained are in agreement with many studies that confirmed similar discordance in HER-2 testing by IHC and/or FISH between local and central laboratory. Thus, our findings as well as of other studies support the importance of regular quality assessment of the staining procedures performed and consistency of interpretation of HER-2 test results.
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Professional paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 54, no. 4, pp. 479-485
p-ISSN1333-9451
URN:NBNurn:nbn:hr:184:926373
Publication2015
Document URLhttp://bib.irb.hr/814237
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-11-13 16:13:09