prikaz prve stranice dokumenta Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands
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Scientific paper - Original scientific paper
Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands
PLoS Pathogens, 6 (2010), 10; e1001150. https://doi.org/10.1371/journal.ppat.1001150
Dölken, Lars; Krmpotić, Astrid; Kothe, Sheila; Tuddenham, Lee; Tanguy, Mélanie; Marcinowski, Lisa; Ruzsics, Zsolt; Elefant, Naama; Altuvia, Yael; Margalit, Hanah; Koszinowski, Ulrich H.; Jonjić, Stipan; Pfeffer, Sébastien

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Dölken, L., Krmpotić, A., Kothe, S., Tuddenham, L., Tanguy, M., Marcinowski, L. ... Pfeffer, S. (2010). Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands. PLoS Pathogens, 6. (10). doi: 10.1371/journal.ppat.1001150

Dölken, Lars, et al. "Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands." PLoS Pathogens, vol. 6, no. 10, 2010. https://doi.org/10.1371/journal.ppat.1001150

Dölken, Lars, Astrid Krmpotić, Sheila Kothe, Lee Tuddenham, Mélanie Tanguy, Lisa Marcinowski, Zsolt Ruzsics, et al. "Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands." PLoS Pathogens 6, no. 10 (2010). https://doi.org/10.1371/journal.ppat.1001150

Dölken, L., et al. (2010) 'Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands', PLoS Pathogens, 6(10). doi: 10.1371/journal.ppat.1001150

Dölken L, Krmpotić A, Kothe S, Tuddenham L, Tanguy M, Marcinowski L, and sur.. Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands. PLoS Pathogens [Internet]. 2010 October 14 [cited 2025 January 18];6(10). doi: 10.1371/journal.ppat.1001150

L. Dölken, et al., "Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands", PLoS Pathogens, vol. 6, no. 10, October 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:298322. [Accessed: 18 January 2025]

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Metadata
Title (english)Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands
AuthorLars Dölken
AuthorAstrid Krmpotić
AuthorSheila Kothe
AuthorLee Tuddenham
AuthorMélanie Tanguy
AuthorLisa Marcinowski
AuthorZsolt Ruzsics
AuthorNaama Elefant
AuthorYael Altuvia
AuthorHanah Margalit
AuthorUlrich H. Koszinowski
AuthorStipan Jonjić
AuthorSébastien Pfeffer
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Micro (mi)RNAs are small non-coding RNAs that regulate the expression of their targets' messenger RNAs through both translational inhibition and regulation of target RNA stability. Recently, a number of viruses, particularly of the herpesvirus family, have been shown to express their own miRNAs to control both viral and cellular transcripts. Although some targets of viral miRNAs are known, their function in a physiologically relevant infection remains to be elucidated. As such, no in vivo phenotype of a viral miRNA knock-out mutant has been described so far. Here, we report on the first functional phenotype of a miRNA knock-out virus in vivo. During subacute infection of a mutant mouse cytomegalovirus lacking two viral miRNAs, virus production is selectively reduced in salivary glands, an organ essential for virus persistence and horizontal transmission. This phenotype depends on several parameters including viral load and mouse genetic background, and is abolished by combined but not single depletion of natural killer (NK) and CD4+ T cells. Together, our results point towards a miRNA-based immunoevasion mechanism important for long-term virus persistence.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePLoS Pathogens
Numberingvol. 6, no. 10, e1001150
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1001150
URN:NBNurn:nbn:hr:184:298322
Publication2010-10-14
ProjectNumber: 062-0621261-1263
Title (croatian): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0621261-1268
Title (croatian): Uloga imunosubverzivnih citomegalovirusnih gena u latenciji
Leader: Astrid Krmpotić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttps://dx.plos.org/10.1371/journal.ppat.1001150
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-08 23:09:24