prikaz prve stranice dokumenta The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
  Download
PDF 894.53 KB
Scientific paper - Original scientific paper
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
Proceedings of the National Academy of Sciences, 106 (2009), 42; 17858-17863. https://doi.org/10.1073/pnas.0903474106
Stanietsky, N.; Šimic, Hrvoje; Arapović, Jurica; Toporik, A.; Levy, O.; Novik, A.; Levine, Z.; Beiman, M.; Dassa, L.; Achdout, H.; Stern-Ginossar, N.; Tsukerman, P.; Jonjić, Stipan; Mandelboim, O.

Cite this document

Stanietsky, N., Šimic, H., Arapović, J., Toporik, A., Levy, O., Novik, A. ... Mandelboim, O. (2009). The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proceedings of the National Academy of Sciences, 106. (42), 17858-17863. doi: 10.1073/pnas.0903474106

Stanietsky, N., et al. "The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity." Proceedings of the National Academy of Sciences, vol. 106, no. 42, 2009, pp. 17858-17863. https://doi.org/10.1073/pnas.0903474106

Stanietsky, N., Hrvoje Šimic, Jurica Arapović, A. Toporik, O. Levy, A. Novik, Z. Levine, et al. "The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity." Proceedings of the National Academy of Sciences 106, no. 42 (2009): 17858-17863. https://doi.org/10.1073/pnas.0903474106

Stanietsky, N., et al. (2009) 'The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity', Proceedings of the National Academy of Sciences, 106(42), pp. 17858-17863. doi: 10.1073/pnas.0903474106

Stanietsky N, Šimic H, Arapović J, Toporik A, Levy O, Novik A, and sur.. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proceedings of the National Academy of Sciences [Internet]. 2009 October 07 [cited 2024 September 10];106(42):17858-17863. doi: 10.1073/pnas.0903474106

N. Stanietsky, et al., "The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity", Proceedings of the National Academy of Sciences, vol. 106, no. 42, pp. 17858-17863, October 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:064979. [Accessed: 10 September 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
AuthorN. Stanietsky
AuthorHrvoje Šimic
AuthorJurica Arapović
AuthorA. Toporik
AuthorO. Levy
AuthorA. Novik
AuthorZ. Levine
AuthorM. Beiman
AuthorL. Dassa
AuthorH. Achdout
AuthorN. Stern-Ginossar
AuthorP. Tsukerman
AuthorStipan Jonjić
AuthorO. Mandelboim
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of the inhibitory receptors bind MHC class I proteins and are expressed in a variegated fashion. It was recently shown that TIGIT, a new protein expressed by T and NK cells binds to PVR and PVR-like receptors and inhibits T cell activity indirectly through the manipulation of DC activity. Here, we show that TIGIT is expressed by all human NK cells, that it binds PVR and PVRL2 but not PVRL3 and that it inhibits NK cytotoxicity directly through its ITIM. Finally, we show that TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytoxicity thus providing an “alternative self” mechanism for MHC class I inhibition.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleProceedings of the National Academy of Sciences
Numberingvol. 106, no. 42, pp. 17858-17863
p-ISSN0027-8424
e-ISSN1091-6490
DOIhttps://doi.org/10.1073/pnas.0903474106
URN:NBNurn:nbn:hr:184:064979
Publication2009-10-07
Publication2009-10-20
Document URLhttp://www.pnas.org/cgi/doi/10.1073/pnas.0903474106
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-08 22:42:17