prikaz prve stranice dokumenta Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology
  Download
PDF 2.41 MB
Scientific paper - Original scientific paper
Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology
The Journal of Immunology, 190 (2012), 3; 1180-1191. https://doi.org/10.4049/jimmunol.1202304
Wensveen, F. M.; Klarenbeek, P. L.; van Gisbergen, K. P. J. M.; Pascutti, M. F.; Derks, I. A. M.; van Schaik, B. D. C.; ten Brinke, A.; de Vries, N.; Cekinović, Đurđica; Jonjić, Stipan; van Lier, R. A. W.; Eldering, E.

Cite this document

Wensveen, F. M., Klarenbeek, P. L., van Gisbergen, K. P. J. M., Pascutti, M. F., Derks, I. A. M., van Schaik, B. D. C. ... Eldering, E. (2012). Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology. The Journal of Immunology, 190. (3), 1180-1191. doi: 10.4049/jimmunol.1202304

Wensveen, F. M., et al. "Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology." The Journal of Immunology, vol. 190, no. 3, 2012, pp. 1180-1191. https://doi.org/10.4049/jimmunol.1202304

Wensveen, F. M., P. L. Klarenbeek, K. P. J. M. van Gisbergen, M. F. Pascutti, I. A. M. Derks, B. D. C. van Schaik, A. ten Brinke, et al. "Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology." The Journal of Immunology 190, no. 3 (2012): 1180-1191. https://doi.org/10.4049/jimmunol.1202304

Wensveen, F. M., et al. (2012) 'Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology', The Journal of Immunology, 190(3), pp. 1180-1191. doi: 10.4049/jimmunol.1202304

Wensveen FM, Klarenbeek PL, van Gisbergen KPJM, Pascutti MF, Derks IAM, van Schaik BDC, and sur.. Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology. The Journal of Immunology [Internet]. 2012 December 31 [cited 2024 November 15];190(3):1180-1191. doi: 10.4049/jimmunol.1202304

F. M. Wensveen, et al., "Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology", The Journal of Immunology, vol. 190, no. 3, pp. 1180-1191, December 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:924563. [Accessed: 15 November 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology
AuthorF. M. Wensveen
AuthorP. L. Klarenbeek
AuthorK. P. J. M. van Gisbergen
AuthorM. F. Pascutti
AuthorI. A. M. Derks
AuthorB. D. C. van Schaik
AuthorA. ten Brinke
AuthorN. de Vries
AuthorĐurđica Cekinović
AuthorStipan Jonjić
AuthorR. A. W. van Lier
AuthorE. Eldering
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Memory T cells form a highly specific defense layer against reinfection with previously encountered pathogens. In addition, memory T cells provide protection against pathogens that are similar, but not identical to the original infectious agent. This is because each T cell response harbors multiple clones with slightly different affinities, thereby creating T cell memory with a certain degree of diversity. Currently, the mechanisms that control size, diversity, and cross-reactivity of the memory T cell pool are incompletely defined. Previously, we established a role for apoptosis, mediated by the BH3-only protein Noxa, in controlling diversity of the effector T cell population. This function might positively or negatively impact T cell memory in terms of function, pool size, and cross-reactivity during recall responses. Therefore, we investigated the role of Noxa in T cell memory during acute and chronic infections. Upon influenza infection, Noxa−/− mice generate a memory compartment of increased size and clonal diversity. Reinfection resulted in an increased recall response, whereas cross-reactive responses were impaired. Chronic infection of Noxa−/− mice with mouse CMV resulted in enhanced memory cell inflation, but no obvious pathology. In contrast, in a model of continuous, high-level T cell activation, reduced apoptosis of activated T cells rapidly led to severe organ pathology and premature death in Noxa-deficient mice. These results establish Noxa as an important regulator of the number of memory cells formed during infection. Chronic immune activation in the absence of Noxa leads to excessive accumulation of primed cells, which may result in severe pathology.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleThe Journal of Immunology
Numberingvol. 190, no. 3, pp. 1180-1191
p-ISSN0022-1767
e-ISSN1550-6606
DOIhttps://doi.org/10.4049/jimmunol.1202304
URN:NBNurn:nbn:hr:184:924563
Publication2012-12-31
Publication2013-02-01
Document URLhttp://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1202304
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-08 14:26:05