prikaz prve stranice dokumenta NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
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Scientific paper - Original scientific paper
NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
Nature Immunology, 19 (2018), 10; 1083-1092. https://doi.org/10.1038/s41590-018-0209-9
Jelenčić, Vedrana; Šestan, Marko; Kavazović, Inga; Lenartić, Maja; Marinović, Sonja; Holmes, Tim D.; Prchal-Murphy, Michaela; Lisnić, Berislav; Sexl, Veronika; Bryceson, Yenan T.; Wensveen, Felix M.; Polić, Bojan

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Jelenčić, V., Šestan, M., Kavazović, I., Lenartić, M., Marinović, S., Holmes, T. D. ... Polić, B. (2018). NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development. Nature Immunology, 19. (10), 1083-1092. doi: 10.1038/s41590-018-0209-9

Jelenčić, Vedrana, et al. "NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development." Nature Immunology, vol. 19, no. 10, 2018, pp. 1083-1092. https://doi.org/10.1038/s41590-018-0209-9

Jelenčić, Vedrana, Marko Šestan, Inga Kavazović, Maja Lenartić, Sonja Marinović, Tim D. Holmes, Michaela Prchal Murphy, et al. "NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development." Nature Immunology 19, no. 10 (2018): 1083-1092. https://doi.org/10.1038/s41590-018-0209-9

Jelenčić, V., et al. (2018) 'NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development', Nature Immunology, 19(10), pp. 1083-1092. doi: 10.1038/s41590-018-0209-9

Jelenčić V, Šestan M, Kavazović I, Lenartić M, Marinović S, Holmes TD, and sur.. NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development. Nature Immunology [Internet]. 2018 September 17 [cited 2024 December 10];19(10):1083-1092. doi: 10.1038/s41590-018-0209-9

V. Jelenčić, et al., "NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development", Nature Immunology, vol. 19, no. 10, pp. 1083-1092, September 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:508103. [Accessed: 10 December 2024]

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Metadata
Title (english)NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
AuthorVedrana Jelenčić
AuthorMarko Šestan
AuthorInga Kavazović
AuthorMaja Lenartić
AuthorSonja Marinović
AuthorTim D. Holmes
AuthorMichaela Prchal-Murphy
AuthorBerislav Lisnić
AuthorVeronika Sexl
AuthorYenan T. Bryceson https://orcid.org/0000-0002-7783-9934
AuthorFelix M. Wensveen
AuthorBojan Polić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The activation of natural killer (NK) cells depends on a change in the balance of signals from inhibitory and activating receptors. The activation threshold values of NK cells are thought to be set by engagement of inhibitory receptors during development. Here, we found that the activating receptor NKG2D specifically set the activation threshold for the activating receptor NCR1 through a process that required the adaptor DAP12. As a result, NKGD2-deficient (Klrk1-/-) mice controlled tumors and cytomegalovirus infection better than wild-type controls through the NCR1-induced production of the cytokine IFN-γ. Expression of NKG2D before the immature NK cell stage increased expression of the adaptor CD3ζ. Reduced expression of CD3ζ in Klrk1-/- mice was associated with enhanced signal transduction through NCR1, and CD3ζ deficiency resulted in hyper-responsiveness to stimulation via NCR1. Thus, an activating receptor developmentally set the activity of another activating receptor on NK cells and determined NK cell reactivity to cellular threats.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleNature Immunology
Numberingvol. 19, no. 10, pp. 1083-1092
p-ISSN1529-2908
e-ISSN1529-2916
DOIhttps://doi.org/10.1038/s41590-018-0209-9
URN:NBNurn:nbn:hr:184:508103
Publication2018-09-17
Publication2018-10
ProjectNumber: 311335
Title (croatian): Next generation sequencing for detection of human primary immunodeficiency syndromes characterized by impaired cytotoxic lymphocyte function
Acronym: SEQ-CYTOTOX
Jurisdiction: eu
Funding stream: FP7
ProjectNumber: IP-2016-06-9306
Title (croatian): Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini
Acronym: INFLAMETAB
Leader: Bojan Polić
Jurisdiction: Croatia
Funding stream: IP
Document URLhttp://www.nature.com/articles/s41590-018-0209-9
Type of resourceText
Access conditionsOpen access
Embargo expiration date: 2019-03-17
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-05 10:31:00