prikaz prve stranice dokumenta Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection
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Scientific paper - Original scientific paper
Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection
Cell Host & Microbe, 13 (2013), 5; 535-545. https://doi.org/10.1016/j.chom.2013.04.007
Jordan, Stefan; Ruzsics, Zsolt; Mitrović, Maja; Baranek, Thomas; Arapović, Jurica; Krmpotić, Astrid; Vivier, Eric; Dalod, Marc; Jonjić, Stipan; Dölken, Lars; Koszinowski, Ulrich H.

Cite this document

Jordan, S., Ruzsics, Z., Mitrović, M., Baranek, T., Arapović, J., Krmpotić, A. ... Koszinowski, U. (2013). Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection. Cell Host & Microbe, 13. (5), 535-545. doi: 10.1016/j.chom.2013.04.007

Jordan, Stefan, et al. "Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection." Cell Host & Microbe, vol. 13, no. 5, 2013, pp. 535-545. https://doi.org/10.1016/j.chom.2013.04.007

Jordan, Stefan, Zsolt Ruzsics, Maja Mitrović, Thomas Baranek, Jurica Arapović, Astrid Krmpotić, Eric Vivier, et al. "Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection." Cell Host & Microbe 13, no. 5 (2013): 535-545. https://doi.org/10.1016/j.chom.2013.04.007

Jordan, S., et al. (2013) 'Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection', Cell Host & Microbe, 13(5), pp. 535-545. doi: 10.1016/j.chom.2013.04.007

Jordan S, Ruzsics Z, Mitrović M, Baranek T, Arapović J, Krmpotić A, and sur.. Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection. Cell Host & Microbe [Internet]. 2013 May [cited 2025 March 21];13(5):535-545. doi: 10.1016/j.chom.2013.04.007

S. Jordan, et al., "Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection", Cell Host & Microbe, vol. 13, no. 5, pp. 535-545, May 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:563319. [Accessed: 21 March 2025]

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Metadata
Title (english)Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection
AuthorStefan Jordan
AuthorZsolt Ruzsics
AuthorMaja Mitrović
AuthorThomas Baranek
AuthorJurica Arapović
AuthorAstrid Krmpotić
AuthorEric Vivier
AuthorMarc Dalod
AuthorStipan Jonjić
AuthorLars Dölken
AuthorUlrich H. Koszinowski
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The immune response against a variety of pathogens can lead to activation of blood formation at ectopic sites, a process termed extramedullary hematopoiesis (EMH). The underlying mechanisms of EMH have been enigmatic. Investigating splenic EMH in mice infected with murine cytomegalovirus (MCMV), we find that, while cells of the adaptive immune system were dispensable for EMH, natural killer (NK) cells were essential. EMH required recognition of infected cells via activating NK cell receptors Ly49H or NKG2D, and correspondingly, viral interference with NK cell recognition abolished EMH. Surprisingly, development of EMH was not induced by NK cell-derived cytokines but was dependent on perforin-mediated cytotoxicity in order to control virus spread. Spreading virus reduced the numbers of F4/80(+) macrophages that were crucial for inflammatory EMH. Hence, whereas MCMV suppresses inflammation-induced EMH, NK cells confine virus spread, thereby protecting extramedullary hematopoietic niches and facilitating EMH.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCell Host & Microbe
Numberingvol. 13, no. 5, pp. 535-545
p-ISSN1931-3128
e-ISSN1934-6069
DOIhttps://doi.org/10.1016/j.chom.2013.04.007
URN:NBNurn:nbn:hr:184:563319
Publication2013-05
ProjectNumber: 268537
Title (english): The Immune function of NK cells
Acronym: THINK
Jurisdiction: eu
Funding stream: FP7
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S1931312813001492
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2018-10-17 19:15:38