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Primitivni neuroektodermalni tumor pluća s pleuralnim izljevom - prikaz slučaja
Medica Jadertina, 48 (2018), 3; 161-168. urn:nbn:hr:184:604620
Flego, Veljko; Volarić, Darian; Zamolo, Gordana; Dekanić, Andrea; Štemberger, Christophe; Griotto, Neva; Petretić Majnarić, Silvana; Divošević, Sunčana; Bulat-Kardum, Ljiljana

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Flego, V., Volarić, D., Zamolo, G., Dekanić, A., Štemberger, C., Griotto, N. ... Bulat Kardum, Lj. (2018). Primitivni neuroektodermalni tumor pluća s pleuralnim izljevom - prikaz slučaja. Medica Jadertina, 48. (3), 161-168. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:604620

Flego, Veljko, et al. "Primitivni neuroektodermalni tumor pluća s pleuralnim izljevom - prikaz slučaja." Medica Jadertina, vol. 48, no. 3, 2018, pp. 161-168. https://urn.nsk.hr/urn:nbn:hr:184:604620

Flego, Veljko, Darian Volarić, Gordana Zamolo, Andrea Dekanić, Christophe Štemberger, Neva Griotto, Silvana Petretić Majnarić, Sunčana Divošević and Ljiljana Bulat Kardum. "Primitivni neuroektodermalni tumor pluća s pleuralnim izljevom - prikaz slučaja." Medica Jadertina 48, no. 3 (2018): 161-168. https://urn.nsk.hr/urn:nbn:hr:184:604620

Flego, V., et al. (2018) 'Primitivni neuroektodermalni tumor pluća s pleuralnim izljevom - prikaz slučaja', Medica Jadertina, 48(3), pp. 161-168. Available at: https://urn.nsk.hr/urn:nbn:hr:184:604620 (Accessed 19 November 2024)

Flego V, Volarić D, Zamolo G, Dekanić A, Štemberger C, Griotto N, and sur.. Primitivni neuroektodermalni tumor pluća s pleuralnim izljevom - prikaz slučaja. Medica Jadertina [Internet]. 2018 August 20 [cited 2024 November 19];48(3):161-168. Available at: https://urn.nsk.hr/urn:nbn:hr:184:604620

V. Flego, et al., "Primitivni neuroektodermalni tumor pluća s pleuralnim izljevom - prikaz slučaja", Medica Jadertina, vol. 48, no. 3, pp. 161-168, August 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:604620. [Accessed: 19 November 2024]

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Metadata
Title (croatian)Primitivni neuroektodermalni tumor pluća s pleuralnim izljevom - prikaz slučaja
Title (english)Primitive neuroectodermal tumor of the lung with pleural effusion - a case report
AuthorVeljko Flego
AuthorDarian Volarić
AuthorGordana Zamolo
AuthorAndrea Dekanić
AuthorChristophe Štemberger
AuthorNeva Griotto
AuthorSilvana Petretić Majnarić
AuthorSunčana Divošević
AuthorLjiljana Bulat-Kardum
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Nuclear Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (croatian)
Uvod: Primitivni neuroektodermalni tumor pluća (PNET) spada u skupinu izrazito malignih tumora, koji se najvećim dijelom javljaju u djece i adolescenata. Ovaj tumor rano metastazira i ima nisku stopu preživljavanja. Prikaz slučaja: 29-godišnja žena tijekom mjesec dana imala je bolove u desnoj strani prsišta i progresivnu zaduhu. Višeslojna kompjutorizirana tomografija (MSCT) prsnoga koša pokazivala je opsežan desnostrani pleuralni izljev i veliku ekspanzivnu tvorbu u gornjem desnom plućnom režnju. Učinjena je torakocenteza, a u pleuralnom izljevu nađene su maligne stanice. Bronhoskopski je viđena vanjska kompresija na bronhe, bez malignih stanica u uzetim uzorcima bronha. U transtorakalnoj, CT-om vođenoj biopsiji tvorbe pluća, histološkom analizom utvrđene su male stanice, s hiperkromatskim jezgrama i atipičnim mitozama. Imunohistokemijski stanice su bile pozitivne na CD99, NSE i CD56 markere. Pozitron-emisijska tomografija kombinirana s kompjutoriziranom tomografijom (PET/CT) pokazivala je jako nakupljanje 18F-fluorodeoksiglukoze u gornjem desnom plućnom režnju i medijastinalnim limfnim čvorovima. Scintigrafijom somatostatinskih receptora (oktreoskan) nađeno je nakupljanje radiofarmaceutika u gornjem desnom plućnom režnju i medijastinumu, čime su utvrđeni somatostatinski receptori u tim dijelovima tijela. Bolesnica je liječena kemoterapijom (cisplatin i etopozid) i oktreotid acetatom, ali PET/CT je pokazivao progresiju tumora, te je provedena palijativna radioterapija. Tumor je brzo progredirao i bolesnica je preminula jedanaest mjeseci nakon utvrđivanja dijagnoze. Zaključak: PNET je agresivni i smrtonosni tumor, te ga treba uzeti u obzir u diferencijalnoj dijagnostici tumora prsnoga koša, bez obzira na dob bolesnika.
Abstract (english)
Introduction: Primitive neuroectodermal tumor (PNET) is a group of rare, highly malignant neoplasms usually found in children and adolescents. The tumor tends to metastasize early, and consequently the survival rate is low. Case report: A 29-year-old female presented with pain in the right side of the thorax and progressive breathlessness of one-month duration. Multi-slice computed tomography (MSCT) of the chest revealed a large pleural effusion in the right hemithorax, and a large expansive formation in the right upper lobe. Thoracentesis was performed, and malignant cells were found in pleural effusion. Bronchoscopic examination revealed extrinsic compression on the bronchi, without malignant cells in the samples taken. Transthoracic MSCT guided biopsy of the mass histologically revealed small cells, with hyperchromatic nuclei and atypical mitosis. Immunohistochemically, the cells were positive for CD99, NSE and CD56. Positron emission tomography (PET) CT revealed intense accumulation of 18F-fluorodeoxyglucose in the right upper lobe and in the mediastinal lymph nodes. Octreoscan showed pathological accumulation of radiopharmaceuticals in the right upper lobe and mediastinum, indicating a lesion with the expression of somatostatin receptor. The patient received chemotherapy (cisplatin and etoposide), and octreotide acetate. PET/CT showed tumor progression. Palliative radiotherapy was administered. The disease progressed rapidly and the patient died subsequently eleven months after the diagnosis. Conclusion: PNET is an aggressive and lethal disease, therefore should be considered in the differential diagnosis of thoracic tumors regardless of the age of the patient.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Professional paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedica Jadertina
Numberingvol. 48, no. 3, pp. 161-168
p-ISSN0351-0093
URN:NBNurn:nbn:hr:184:604620
Publication2018-08-20
Document URLhttps://hrcak.srce.hr/204758
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-10-17 16:38:05