prikaz prve stranice dokumenta ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma
  Download
PDF 458.28 KB
Scientific paper - Original scientific paper
ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma
European Journal of Immunology, 41 (2011), 7; 1902-1912. https://doi.org/10.1002/eji.201141417
Jovanović, Ivan; Radosavljević, Gordana; Mitrović, Maja; Juranić Lisnić, Vanda; McKenzie, Andrew; Arsenijević, Nebojša; Jonjić, Stipan; Lukić, Miodrag

Cite this document

Jovanović, I., Radosavljević, G., Mitrović, M., Juranić Lisnić, V., McKenzie, A., Arsenijević, N. ... Lukić, M. (2011). ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma. European Journal of Immunology, 41. (7), 1902-1912. doi: 10.1002/eji.201141417

Jovanović, Ivan, et al. "ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma." European Journal of Immunology, vol. 41, no. 7, 2011, pp. 1902-1912. https://doi.org/10.1002/eji.201141417

Jovanović, Ivan, Gordana Radosavljević, Maja Mitrović, Vanda Juranić Lisnić, Andrew McKenzie, Nebojša Arsenijević, Stipan Jonjić and Miodrag Lukić. "ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma." European Journal of Immunology 41, no. 7 (2011): 1902-1912. https://doi.org/10.1002/eji.201141417

Jovanović, I., et al. (2011) 'ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma', European Journal of Immunology, 41(7), pp. 1902-1912. doi: 10.1002/eji.201141417

Jovanović I, Radosavljević G, Mitrović M, Juranić Lisnić V, McKenzie A, Arsenijević N, and sur.. ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma. European Journal of Immunology [Internet]. 2011 [cited 2025 January 22];41(7):1902-1912. doi: 10.1002/eji.201141417

I. Jovanović, et al., "ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma", European Journal of Immunology, vol. 41, no. 7, pp. 1902-1912, 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:883531. [Accessed: 22 January 2025]

Please login to the repository to save this object to your list.
Metadata
Title (english)ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma
AuthorIvan Jovanović
AuthorGordana Radosavljević
AuthorMaja Mitrović
AuthorVanda Juranić Lisnić
MBZ: 296602
AuthorAndrew McKenzie
AuthorNebojša Arsenijević
AuthorStipan Jonjić
AuthorMiodrag Lukić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
ST2 is a member of the IL-1 receptor family and IL-33 was recently identified as its natural ligand. The IL-33/ST2 pathway regulates Th1/Th2 immune responses in autoimmune and inflammatory conditions, but the role of ST2 signaling in tumor growth and metastasis has not been investigated. We aimed to investigate whether ST2 gene deletion affects tumor appearance, growth, and metastasis, and antitumor immunity in an experimental metastatic breast cancer model. Deletion of ST2 in BALB/c mice bearing mammary carcinoma attenuated tumor growth and metastasis, which was accompanied by increased serum levels of IL-17, IFN-γ, and TNF-α and decreased IL-4. Tumor-bearing ST2−/− mice had significantly higher percentages of activated CD27highCD11bhigh NK cells, CD69+ and KLRG− NK cells and higher cytotoxic activity of splenocytes, NK cells, and CD8+ T cells in vitro. A significantly higher number of NK cells expressing IFN-γ were found in ST2−/− mice compared with WT recipients. In vivo depletion of CD8+ or NK cells revealed a key role for NK cells in enhanced antitumor immunity in ST2−/− mice. We report for the first time that suppressed breast cancer progression and metastasis in mice lacking ST2 corresponds mainly with enhanced cytotoxic activity of NK cells, and increased systemic Th1/Th17 cytokines.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEuropean Journal of Immunology
Numberingvol. 41, no. 7, pp. 1902-1912
p-ISSN0014-2980
e-ISSN1521-4141
DOIhttps://doi.org/10.1002/eji.201141417
URN:NBNurn:nbn:hr:184:883531
Publication2011
Document URLhttp://bib.irb.hr/517771
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-10-15 06:07:45