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master's thesis
Hijaluronska kiselina u parodontologiji
2018. urn:nbn:hr:184:035731
Križaić, Klara
University of Rijeka
Faculty of Medicine
Department of Oral Medicine and Periodontology

Cite this document

Križaić, K. (2018). Hijaluronska kiselina u parodontologiji (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:035731

Križaić, Klara. "Hijaluronska kiselina u parodontologiji." Master's thesis, University of Rijeka, Faculty of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:184:035731

Križaić, Klara. "Hijaluronska kiselina u parodontologiji." Master's thesis, University of Rijeka, Faculty of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:184:035731

Križaić, K. (2018). 'Hijaluronska kiselina u parodontologiji', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:184:035731

Križaić K. Hijaluronska kiselina u parodontologiji [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2018 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:184:035731

K. Križaić, "Hijaluronska kiselina u parodontologiji", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:184:035731

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Metadata
TitleHijaluronska kiselina u parodontologiji
Title (english)Hyaluronic acid in periodontology
AuthorKlara Križaić
MentorJelena Prpić (mentor)
Committee memberJelena Prpić (predsjednik povjerenstva)
Committee memberIrena Glažar (član povjerenstva)
Committee memberAlen Braut (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Oral Medicine and Periodontology)
Rijeka
Defense date and country2018-07-19, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Periodontology
Abstract
Hijaluronska kiselina je kompleksni ugljikohidrat, točnije mukopolisaharid koji se nalazi u svim živim organizmima. Primarno se nalazi u izvanstaničnom matriksu, a njezine uloge u ljudskom organizmu su brojne. Prije više od 80 godina otkrili su je Meyer i Palmer ekstrakcijom iz goveđe staklovine oka. Hijaluronska kiselina je linearni polimer iznimne molekularne težine, sintetizira se u staničnoj membrani plazme uz pomoć visoko specijaliziranih membranskih proteina HAS1, HAS2 i HAS3. Osim u kralježaka nalazimo je i u nekim bakterijama i virusima. S obzirom na veliku rasprostranjenost u organizmu nalazimo je i u slini, gingivnoj tekućini te potpornim tkivima zuba. U parodontologiji hijaluronska kiselina se koristi kao monoterapija ili kao dodatak nekirurškoj i/ili kirurškoj parodontološkoj terapiji. Terapija gingivitisa i parodontitisa je uspješnija kada se kombinira mehanička terapija i hijaluronska kiselina koja ima učinak na kontrolu upale, smanjenje krvarenja gingive te djeluje bakteriostatski. Također je možemo koristiti kod rekonstrukcije interdentalne papile kako bi izbjegli operativni zahvat. Hijaluronska kiselina primjenjena zajedno s hidroksiapatitom i β-trikalcij fosfatom nakon ekstrakcije zuba potiče stvaranje nove kosti i očuvanje postekstrakcijske alveole. Važna je komponenta u reakcijama cijeljenja rana jer djeluje na ekspresiju gena fibroblasta, potiče sintezu kolagena te adheziju i proliferaciju stanica. Hijaluronska kiselina može se koristiti i nakon postavljanja implantata jer utječe na primarnu osteointegraciju istog.
Abstract (english)
Hyaluronic acid is a carbohydrate, more specifically a mucopolysaccharide, occuring in all living organisms. It is found primarily in the extracellular matrix and its functions in human body are numerous. Over 80 years have passed since the discovery of hyaluronic acid, when Meyer and Palmer extracted it from bovine vitreous humor. It is a linear polymer of exceptional molecular weight and is synthesized in the cellular plasma membrane with help of plasma membrane proteins HAS1, HAS2 and HAS3. Except vertebrates, hyaluronic acid is also found in some bacteria and viruses. Hyaluronic acid may be found in saliva, gingival crevicular fluid and the periodontium. In periodontology it has been used as monotherapy or as adjunct to non-surgical and/or surgical periodontal treatment. Therapy of gingivitis and periodontitis has yielded better results if mechanical therapy was combined with hyaluronic acid which controls inflammation, reduces gingival bleeding and has a bacteriostatic effect.Hyaluronic acid may also be used in interdental papilla loss treatment instead of an operation. Combination of hyaluronic acid, hydroxyapatite and beta tricalcium phosphate has very good effects in osteoconduction and preservation of alveolar sockets. Hyaluronic acid plays an important role in wound healing where it acts on the expression of fibroblasts, stimulates synthesis of collagen and adhesion and cell proliferation. Dental implants coated with hyaluronic acid have good primary osteointegration.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:035731
Study programmeTitle: Dental Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2018-10-02 09:45:35