prikaz prve stranice dokumenta Multiple Myeloma Index for Risk of Infection
  Download
PDF 342.51 KB
Scientific paper - Preliminary note / Short communication
Multiple Myeloma Index for Risk of Infection
Journal of Cancer, 9 (2018), 12; 2211-2214. https://doi.org/10.7150/jca.24288.
Valković, Toni; Gačić, Vedrana; Načinović-Duletic, Antica

Citations:
,
Cite this document

Valković, T., Gačić, V. & Načinović Duletic, A. (2018). Multiple Myeloma Index for Risk of Infection. Journal of Cancer, 9. (12), 2211-2214. doi: 10.7150/jca.24288.

Valković, Toni, et al. "Multiple Myeloma Index for Risk of Infection." Journal of Cancer, vol. 9, no. 12, 2018, pp. 2211-2214. https://doi.org/10.7150/jca.24288.

Valković, Toni, Vedrana Gačić and Antica Načinović Duletic. "Multiple Myeloma Index for Risk of Infection." Journal of Cancer 9, no. 12 (2018): 2211-2214. https://doi.org/10.7150/jca.24288.

Valković, T., Gačić, V. and Načinović Duletic, A. (2018) 'Multiple Myeloma Index for Risk of Infection', Journal of Cancer, 9(12), pp. 2211-2214. doi: 10.7150/jca.24288.

Valković T, Gačić V, Načinović Duletic A. Multiple Myeloma Index for Risk of Infection. Journal of Cancer [Internet]. 2018 [cited 2025 April 12];9(12):2211-2214. doi: 10.7150/jca.24288.

T. Valković, V. Gačić and A. Načinović Duletic, "Multiple Myeloma Index for Risk of Infection", Journal of Cancer, vol. 9, no. 12, pp. 2211-2214, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:589793. [Accessed: 12 April 2025]

Please login to the repository to save this object to your list.
Metadata
Title (english)Multiple Myeloma Index for Risk of Infection
AuthorToni Valković
AuthorVedrana Gačić
AuthorAntica Načinović-Duletic
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Based on our earlier research into the main characteristics and risk factors for infections in hospitalized patients with multiple myeloma, we created the numerical Multiple Myeloma Index for Risk of Infection (MMIRI) to predict infection in myeloma patients. The included factors that could influence the pathogenesis and incidence of infections were sex, perform ance status, Durie Salmon stage of disease, International Staging System, serum creatinine level, immune... More paresis, neutropenia, serum ferritin level, the presence of any catheters, disease duration, stable/progressive disease, and type of therapy. For each of these parameters, the strength of association with infection was statistically estimated and specific number of points was assigned to each of these parameters, proportional to the strength of the association. When designing the MMIRI, we included only those parameters that we determined were pathophysiologically associated with the infection. After further statistical analysis, we identified an optimal cutoff score of 6 or above as indicating a significant risk for infection, with a sensitivity of 93.2% and specificity of 80.2%. The scoring system in the retrospective receiver operating characteristic analysis showed an area under the curve of 0.918. The potential value of the MMIRI is the possibility of identifying those patients who would benefit from the prophylactic administration of antibiotics and other anti -infective measures while minimizing the contribution to antibiotic resistance related to the overuse of these drugs. As far as we know, this index represents the first attempt to create such an instrument for predicting the occurrence of infections in myeloma patients. Less
Languageenglish
Publication typeScientific paper - Preliminary note / Short communication
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Cancer
Numberingvol. 9, no. 12, pp. 2211-2214
e-ISSN1837-9664
DOIhttps://doi.org/10.7150/jca.24288.
URN:NBNurn:nbn:hr:184:589793
Publication2018
Document URLhttp://www.jcancer.org/v09p2211.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-09-29 13:06:08
accessibility

closeAccessibilityrefresh

If you wish to permanently save changes, click on Save, if not - your settings will be reset when you restart the browser.