Cell DeathMechanisms at theMaternal-Fetal Interface:
 Insights into the Role of Granulysin

Veljković Vujaklija, Danijela; Sučić, Sonja; Gulić, Tamara; Dominović, Marin; Rukavina, Daniel

doi:10.1155/2012/180272

prikaz prve stranice dokumenta Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin

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Scientific paper - Review paper

Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin

Clinical and Developmental Immunology, 2012 (2012); 180272. https://doi.org/10.1155/2012/180272

Veljković Vujaklija, Danijela; Sučić, Sonja; Gulić, Tamara; Dominović, Marin; Rukavina, Daniel

Cite this document

APA 6th Edition

Veljković Vujaklija, D., Sučić, S., Gulić, T., Dominović, M. & Rukavina, D. (2012). Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin. Clinical and Developmental Immunology, 2012.. doi: 10.1155/2012/180272

MLA 8th Edition

Veljković Vujaklija, Danijela, et al. "Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin." Clinical and Developmental Immunology, vol. 2012, 2012. https://doi.org/10.1155/2012/180272

Chicago 17th Edition

Veljković Vujaklija, Danijela, Sonja Sučić, Tamara Gulić, Marin Dominović and Daniel Rukavina. "Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin." Clinical and Developmental Immunology 2012 (2012). https://doi.org/10.1155/2012/180272

Harvard

Veljković Vujaklija, D., et al. (2012) 'Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin', Clinical and Developmental Immunology, 2012. doi: 10.1155/2012/180272

Vancouver

Veljković Vujaklija D, Sučić S, Gulić T, Dominović M, Rukavina D. Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin. Clinical and Developmental Immunology [Internet]. 2012 [cited 2024 November 15];2012. doi: 10.1155/2012/180272

IEEE

D. Veljković Vujaklija, S. Sučić, T. Gulić, M. Dominović and D. Rukavina, "Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin", Clinical and Developmental Immunology, vol. 2012, 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:273439. [Accessed: 15 November 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:184:273439

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Metadata

Title (english)	Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin
Author	Danijela Veljković Vujaklija
Author	Sonja Sučić
Author	Tamara Gulić
Author	Marin Dominović
Author	Daniel Rukavina
Author's institution	University of Rijeka (Faculty of Biotechnology and Drug Development)
Author's institution	University of Rijeka Faculty of Medicine (Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences
Abstract (english)	During mammal pregnancy, a sensitive balance between hormones, cytokines, humoral factors, and local cellular interactions must be established. Cytotoxic cells infiltrating the decidua are heavily equipped with cytolytic molecules, in particular perforin and granulysin. Granulysin is especially abundant in NK cells which are able to spontaneously secrete high quantities of granulysin. Besides being a potent bactericidal and tumoricidal molecule, granulysin is also found to be a chemoattractant and a proinflammatory molecule. The precise role(s) of granulysin at the maternal-fetal interface has not been elucidated yet. It is possible that it behaves as a double-edged sword simultaneously acting as an immunomodulatory and a host defense molecule protecting both the mother and the fetus from a wide spectrum of pathogens, and on the other hand, in case of an NK cell activation, acting as an effector molecule causing the apoptosis of semiallograft trophoblast cells and consequently leading to various pregnancy disorders or pregnancy loss.
Language	english
Publication type	Scientific paper - Review paper
Publication status	Published
Peer review	Peer review - international
Publication version	Published version
Journal title	Clinical and Developmental Immunology
Numbering	vol. 2012, 180272
p-ISSN	1740-2522
e-ISSN	1740-2530
DOI	https://doi.org/10.1155/2012/180272
URN:NBN	urn:nbn:hr:184:273439
Publication	2012
Type of resource	Text
Access conditions	Open access
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Created on	2018-07-31 07:02:06