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Scientific paper - Original scientific paper
ANALIZA PROGNOSTIČKIH ČIMBENIKA I NAČINA LIJEČENJA U BOLESNICA S RAKOM ENDOMETRIJA U PRVOM FIGO STADIJU
Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, 13 (2004), 4; 149-154. urn:nbn:hr:184:920799
Haller, Herman; Kraševic, Maja; Stanković, Teodora; Kovač, Drazen; Karnjuš-Begonja, Ružica; Rupčić, Stanislav; Mamula, Ozren; Mozetič, Darko; Stamatović, Miroslav; Manestar, Miljenko; Brnčić-Fischer, Alemka; Sindik, Nebojša

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Haller, H., Kraševic, M., Stanković, T., Kovač, D., Karnjuš Begonja, R., Rupčić, S. ... Sindik, N. (2004). ANALIZA PROGNOSTIČKIH ČIMBENIKA I NAČINA LIJEČENJA U BOLESNICA S RAKOM ENDOMETRIJA U PRVOM FIGO STADIJU. Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, 13. (4), 149-154. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:920799

Haller, Herman, et al. "ANALIZA PROGNOSTIČKIH ČIMBENIKA I NAČINA LIJEČENJA U BOLESNICA S RAKOM ENDOMETRIJA U PRVOM FIGO STADIJU." Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, vol. 13, no. 4, 2004, pp. 149-154. https://urn.nsk.hr/urn:nbn:hr:184:920799

Haller, Herman, Maja Kraševic, Teodora Stanković, Drazen Kovač, Ružica Karnjuš Begonja, Stanislav Rupčić, Ozren Mamula, et al. "ANALIZA PROGNOSTIČKIH ČIMBENIKA I NAČINA LIJEČENJA U BOLESNICA S RAKOM ENDOMETRIJA U PRVOM FIGO STADIJU." Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics 13, no. 4 (2004): 149-154. https://urn.nsk.hr/urn:nbn:hr:184:920799

Haller, H., et al. (2004) 'ANALIZA PROGNOSTIČKIH ČIMBENIKA I NAČINA LIJEČENJA U BOLESNICA S RAKOM ENDOMETRIJA U PRVOM FIGO STADIJU', Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, 13(4), pp. 149-154. Available at: https://urn.nsk.hr/urn:nbn:hr:184:920799 (Accessed 10 December 2024)

Haller H, Kraševic M, Stanković T, Kovač D, Karnjuš Begonja R, Rupčić S, and sur.. ANALIZA PROGNOSTIČKIH ČIMBENIKA I NAČINA LIJEČENJA U BOLESNICA S RAKOM ENDOMETRIJA U PRVOM FIGO STADIJU. Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics [Internet]. 2004 December 01 [cited 2024 December 10];13(4):149-154. Available at: https://urn.nsk.hr/urn:nbn:hr:184:920799

H. Haller, et al., "ANALIZA PROGNOSTIČKIH ČIMBENIKA I NAČINA LIJEČENJA U BOLESNICA S RAKOM ENDOMETRIJA U PRVOM FIGO STADIJU", Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, vol. 13, no. 4, pp. 149-154, December 2004. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:920799. [Accessed: 10 December 2024]

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Metadata
Title (croatian)ANALIZA PROGNOSTIČKIH ČIMBENIKA I NAČINA LIJEČENJA U BOLESNICA S RAKOM ENDOMETRIJA U PRVOM FIGO STADIJU
Title (english)ANALYSIS OF PROGNOSTIC FACTORS AND OF TYPE OF TREATMENT IN PATIENTS WITH ENDOMETRIAL CANCER IN THE FIRST FIGO STAGE
AuthorHerman Haller
AuthorMaja Kraševic
AuthorTeodora Stanković
AuthorDrazen Kovač
AuthorRužica Karnjuš-Begonja
AuthorStanislav Rupčić
AuthorOzren Mamula
AuthorDarko Mozetič
AuthorMiroslav Stamatović
AuthorMiljenko Manestar
AuthorAlemka Brnčić-Fischer
AuthorNebojša Sindik
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (croatian)
Cilj rada. Ispitati važnost histopatoloških čimbenika rizika i svrsishodnost načina liječenja u bolesnica s rakom endometrija u kirurškom – FIGO stadiju I. Metode. Retrospektivno je izdvojeno 219 bolesnica s rakom endometrija u kojih je učinjen sveobuhvatni staging (lavat negativan, limfne žlijezde negativne). Srednja dob bolesnica iznosila je 59 godina (SD 8, min. 39, maks. 75 godina). Vrijeme promatranja iznosilo je od 1 do 180 mjeseci, medijana 68 mjeseci. Analizirani su u odnosu na petogodišnje preživljenje sljedeći prognostički čimbenici: dob bolesnice, dubina invazije miometrija, histologija i diferenciranost tumora, vrsta histerektomije i primjena adjuvantne radioterapije. U 85 bolesnica učinjena je radikalna histerektomija, dok je njih 55 primilo adjuvantnu radioterapiju. Rezultati. Ukupno preživljenje promatrane skupine bolesnica iznosi 92,8%. Analizom svih prognostičkih parametara nije nađena značajnost u razlici preživljenja. Od 219 bolesnica njih 82 (37,4%) imale su kumulativne negativne prognostičke čimbenike, slabo diferencirani tumor ili neendometrioidni histološki nalaz ili invaziju miometrija preko polovice, a preživljenje između visoko rizične i nisko rizične skupine se bitno ne razlikuje (93,9% odnosno 91,2%). Primjena radikalne histerektomije uz adjuvantnu radioterapiju ne daje bolje rezultate preživljenja od radikalne histerektomije. Zaključak. Prema našoj retrospektivnoj analizi čimbenika rizika u bolesnica s rakom endometrija prvog FIGO stadija, analizirani čimbenici rizika nemaju prognostičko obilježje. Primjena radikalne histerektomije s ili bez adjuvantne radioterapije zdjelice ne pruža bolje rezultate u smislu preživljenja, i daljnju primjenu treba temeljito preispitati.
Abstract (english)
Objective. To analyze the effect of histopathologic characteristics and usefullness of therapy mode in FIGO stage I endometrial cancer patients. Methods. Retrospectively were analyzed 219 endometrial cancer patients with hysterectomy, salpingoophorectomy and pelvic lymphadenectomy (peritoneal cytology and nodes negative). Patients characteristics include age, myometrial invasion, FIGO substages, histologic type, tumor grade, type of hysterectomy and adjuvant radio¬therapy. The mean age was 59 years (SD 8, Min. 39, Max. 75 years). Follow up ranges from 1 to 180 months (median 68). In 85 patients radical hysterectomies were performed and 45 patients received adjuvant radiotherapy. Results. Five year disease related survival was 92,8%. There is no significant difference among analyzed histopathologic patient’s characteristics related to five years survival. In 82 (37.3%) patients out of 219 were found cumulative negative prognostic factors (high risk patients) including non-endometrioid histology, poor tumor differentiation and/or outer half of miometrial invasion. There is no difference in survival between low (91,2%) and high risk patients (93,9%). Radical hysterectomy as well as adjuvant radiotherapy has no advantage in five year survival. Conclusion. This retrospective study has not identified histopathologic prognostic significant characteristics in FIGO stage I endometrial cancer patients. The use of radical hysterectomy and/or adjuvant radiotherapy has not better five years survival and should be reevaluated.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleGynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics
Numberingvol. 13, no. 4, pp. 149-154
p-ISSN1330-0091
URN:NBNurn:nbn:hr:184:920799
Publication2004-12-01
Document URLhttps://hrcak.srce.hr/15597
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-07-30 19:46:48