Approximately, 44 million abortions worldwide are carried out annually. In the Republic of Croatia 2015, 8 362 abortions (reported) were performed, out of 1 319 were spontaneous. Spontaneous or abdominal abortions can be caused by various causes, and most commonly they include abnormal embryos, immune disorders, endocrinopathy, mother or child disease, uterine abnormalities, and various environmental pollutants. In over of 60% of cases chromosomal abnormalities are present. Spontaneous abortion or early pregnancy loss can greatly affect the reduction of the quality of life of a woman and their family, and besides of emotional and psychological aspects, it represents a major socioeconomic problem. A medically terminated early pregnancy is performed using two drugs, mifepristone, a synthetic steroid that binds to the progesterone receptor with much higher progestogen affinity, and misoprostol that is a cheap analogue of prostaglandin E1. In the world, there are various protocols for the use of these drugs, and the most successful method of early pregnancy interruptions is the combination of these two drugs. As an alternative protocol, methotrexate can be used although it is not recommended by the World Health Organization. As an inescapable question, there is also the question of an invocation of conscientious objection not clearly regulated in Republic of Croatia. The medically terminated pregnancy as a modern method of interrupting pregnancy has certain advantages over surgical methods, and most importantly, the safety and the more natural method of treatment are mentioned.