By intertwining the changes of the joint cartilage and the subhondral bone, the disparity between the demand and the capacity for transfer and absorption of the pressure force increases. A large range of changes in cartilage and subhondral bone are clinically manifested from barely noticeable to well-developed diseases. Due to the progression of the articular cartilage degeneration, the subhondral bone becomes firmer, more rigid and loses high elastic properties. Cartilage also becomes non-elastic, fragile and prone to breakage which is the result of changes in matrix content and loss of water. Cartilage soon after loses its biomechanical properties, which ultimately results in a lower ability to absorb the load on the subhondral bone. Further sclerosis of the subhondral bones reverses the load of the joint cartilage and thus closes the circle. Changes in the joint cartilage were analyzed according to Mankin's grading scale, where the cartilage surface is estimated, changes in the amount of proteoglycan in the matrix, cell and tidemark. The degree of change is evaluated by the numbers that are finally summed and thus the degree of cartilage degeneration is obtained. This division of results highlights the differences in the thickness of the subhondral compact layer in relation to the degree of degenerative changes. Also, all other parameters of the subhondral trabecular bone support severe degenerative cartilage changes and show that trabecular bones are making strong changes such as, for example, high BV / TV. The most significant is the relationship between BV / TV and the thickness of the subhondral compacted layer of bone in each group according to the degree of cartilage degeneration.