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Scientific paper - Review paper
The “Big Bang” in obese fat: Events initiatingobesity-induced adipose tissue inflammation
European Journal of Immunology, 45 (2015); 2446-2456. https://doi.org/10.1002/eji.201545502
Wensveen, Felix M.; Valentić, Sonja; Šestan, Marko; Turk Wensveen, Tamara; Polić, Bojan

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Wensveen, F. M., Valentić, S., Šestan, M., Turk Wensveen, T. & Polić, B. (2015). The “Big Bang” in obese fat: Events initiatingobesity-induced adipose tissue inflammation. European Journal of Immunology, 45., 2446-2456. doi: 10.1002/eji.201545502

Wensveen, Felix M., et al. "The “Big Bang” in obese fat: Events initiatingobesity-induced adipose tissue inflammation." European Journal of Immunology, vol. 45, 2015, pp. 2446-2456. https://doi.org/10.1002/eji.201545502

Wensveen, Felix M., Sonja Valentić, Marko Šestan, Tamara Turk Wensveen and Bojan Polić. "The “Big Bang” in obese fat: Events initiatingobesity-induced adipose tissue inflammation." European Journal of Immunology 45 (2015): 2446-2456. https://doi.org/10.1002/eji.201545502

Wensveen, F. M., et al. (2015) 'The “Big Bang” in obese fat: Events initiatingobesity-induced adipose tissue inflammation', European Journal of Immunology, 45, pp. 2446-2456. doi: 10.1002/eji.201545502

Wensveen FM, Valentić S, Šestan M, Turk Wensveen T, Polić B. The “Big Bang” in obese fat: Events initiatingobesity-induced adipose tissue inflammation. European Journal of Immunology [Internet]. 2015 [cited 2024 April 16];45:2446-2456. doi: 10.1002/eji.201545502

F. M. Wensveen, S. Valentić, M. Šestan, T. Turk Wensveen and B. Polić, "The “Big Bang” in obese fat: Events initiatingobesity-induced adipose tissue inflammation", European Journal of Immunology, vol. 45, pp. 2446-2456, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:297766. [Accessed: 16 April 2024]

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Metadata
Title (english)The “Big Bang” in obese fat: Events initiatingobesity-induced adipose tissue inflammation
AuthorFelix M. Wensveen
AuthorSonja Valentić
AuthorMarko Šestan
AuthorTamara Turk Wensveen
AuthorBojan Polić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Obesity is associated with the accumulation of pro-inflammatory cells in visceral adiposetissue (VAT), which is an important underlying cause of insulin resistance and progres-sion to diabetes mellitus type 2 (DM2). Although the role of pro-inflammatory cytokinesin disease development is established, the initiating events leading to immune cell acti-vation remain elusive. Lean adipose tissue is predominantly populated with regulatorycells, such as eosinophils and type 2 innate lymphocytes. These cells maintain tissuehomeostasis through the excretion of type 2 cytokines, such as IL-4, IL-5, and IL-13,which keep adipose tissue macrophages (ATMs) in an anti-inflammatory, M2-like state.Diet-induced obesity is associated with the loss of tissue homeostasis and developmentof type 1 inflammatory responses in VAT, characterized by IFN-γ. A key event is a shiftof ATMs toward an M1 phenotype. Recent studies show that obesity-induced adipocytehypertrophy results in upregulated surface expression of stress markers. Adipose stressis detected by local sentinels, such as NK cells and CD8+T cells, which produce IFN-γ,driving M1 ATM polarization. A rapid accumulation of pro-inflammatory cells in VATfollows, leading to inflammation. In this review, we provide an overview of events lead-ing to adipose tissue inflammation, with a special focus on adipose homeostasis and theobesity-induced loss of homeostasis which marks the initiation of VAT inflammation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEuropean Journal of Immunology
Numberingvol. 45, pp. 2446-2456
p-ISSN0014-2980
e-ISSN1521-4141
DOIhttps://doi.org/10.1002/eji.201545502
URN:NBNurn:nbn:hr:184:297766
Publication2015
Document URLhttps://doi.org/10.1002/eji.201545502
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-03-21 07:32:05