prikaz prve stranice dokumenta Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia
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Scientific paper - Original scientific paper
Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia
Basic and Clinical Pharmacology and Toxicology, 121 (2017), 6; 453-464. https://doi.org/10.1111/bcpt.12833
Mršić-Pelčić, Jasenka; Pilipović, Kristina; Pelčić, Goran; Vitezić, Dinko; Župan, Gordana

Cite this document

Mršić Pelčić, J., Pilipović, K., Pelčić, G., Vitezić, D. & Župan, G. (2017). Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia. Basic and Clinical Pharmacology and Toxicology, 121. (6), 453-464. doi: 10.1111/bcpt.12833

Mršić Pelčić, Jasenka, et al. "Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia." Basic and Clinical Pharmacology and Toxicology, vol. 121, no. 6, 2017, pp. 453-464. https://doi.org/10.1111/bcpt.12833

Mršić Pelčić, Jasenka, Kristina Pilipović, Goran Pelčić, Dinko Vitezić and Gordana Župan. "Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia." Basic and Clinical Pharmacology and Toxicology 121, no. 6 (2017): 453-464. https://doi.org/10.1111/bcpt.12833

Mršić Pelčić, J., et al. (2017) 'Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia', Basic and Clinical Pharmacology and Toxicology, 121(6), pp. 453-464. doi: 10.1111/bcpt.12833

Mršić Pelčić J, Pilipović K, Pelčić G, Vitezić D, Župan G. Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia. Basic and Clinical Pharmacology and Toxicology [Internet]. 2017 December [cited 2024 December 10];121(6):453-464. doi: 10.1111/bcpt.12833

J. Mršić Pelčić, K. Pilipović, G. Pelčić, D. Vitezić and G. Župan, "Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia", Basic and Clinical Pharmacology and Toxicology, vol. 121, no. 6, pp. 453-464, December 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:219197. [Accessed: 10 December 2024]

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Metadata
Title (english)Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia
AuthorJasenka Mršić-Pelčić
AuthorKristina Pilipović
AuthorGoran Pelčić
AuthorDinko Vitezić
AuthorGordana Župan
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Recombinant human erythropoietin (rhEpo) is a multi-functional drug with antioxidant potential. However, the underlying molecular mechanisms of its action are still unclear. The purpose of this study was to investigate the effects of rhEpo on the brain infarct volume as well as on the levels of the neuronal damage, oxidative stress parameters and active caspase-3, nuclear factor erythroid 2-related factor 2 (Nrf2) and haemeoxygenase-1 (HO-1) expressions in the hippocampi of rats exposed to the right middle cerebral artery occlusion (MCAO) for 1hr. Ischaemic animals received either vehicle or rhEpo (5000IU/kg, i.p.) immediately or 3hr after the induction of ischaemia. Sham-operated, vehicle-treated animals served as the control group. Rats were killed 24hr after the onset of the ischaemic or sham experimental procedure. MCAO caused ipsilateral brain infarction within the striatum and cortex. In the CA1 region of the hippocampi, we did not find significant neuronal loss, but a statistically significant rise in the active caspase-3 and Nrf2 protein expressions was registered. We detected also significant increases in the hippocampal levels of oxidative stress parameters (thiobarbituric acid-reactive substances, superoxide dismutase, glutathione peroxidase). Post-ischaemic administration of rhEpo significantly reduced the brain infarct volume, decreased levels of all tested oxidative stress parameters and increased the Nrf2 expression level. These findings suggest that decrease in oxidative stress parameters in the hippocampus could be an early indicator of post-ischaemic neuroprotective effect of rhEpo in rats exposed to focal cerebral ischaemia and that this effect could be attributable to additional post-ischaemic activation of Nrf2 endogenous antioxidant system.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBasic and Clinical Pharmacology and Toxicology
Numberingvol. 121, no. 6, pp. 453-464
p-ISSN1742-7851
DOIhttps://doi.org/10.1111/bcpt.12833
URN:NBNurn:nbn:hr:184:219197
Publication2017-12
ProjectNumber: 62-0620529-0518
Title (croatian): Molekularni mehanizmi ishemijskog oštećenja mozga i neuroprotekcija
Leader: Jasenka Mršić Pelčić
Jurisdiction: Croatia
ProjectNumber: 62-0620529-0519
Title (croatian): Epilepsija i traumatska ozljeda mozga: mehanizmi oštećenja i farmakoterapija
Leader: Gordana Župan
Jurisdiction: Croatia
Document URLhttp://bib.irb.hr/datoteka/909186.Rad2017.pdf
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2017-12-27 21:54:25