prikaz prve stranice dokumenta Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients
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Scientific paper - Original scientific paper
Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients
Biomarkers, 22 (2017), 8; 790-797. https://doi.org/10.1080/1354750X.2017.1351001
Bonifačić, David; Aralica, Merica; Sotošek Tokmadžić, Vlatka; Rački, Valentino; Tuškan-Mohar, Lidija; Kučić, Natalia

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Bonifačić, D., Aralica, M., Sotošek Tokmadžić, V., Rački, V., Tuškan Mohar, L. & Kučić, N. (2017). Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients. Biomarkers, 22. (8), 790-797. doi: 10.1080/1354750X.2017.1351001

Bonifačić, David, et al. "Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients." Biomarkers, vol. 22, no. 8, 2017, pp. 790-797. https://doi.org/10.1080/1354750X.2017.1351001

Bonifačić, David, Merica Aralica, Vlatka Sotošek Tokmadžić, Valentino Rački, Lidija Tuškan Mohar and Natalia Kučić. "Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients." Biomarkers 22, no. 8 (2017): 790-797. https://doi.org/10.1080/1354750X.2017.1351001

Bonifačić, D., et al. (2017) 'Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients', Biomarkers, 22(8), pp. 790-797. doi: 10.1080/1354750X.2017.1351001

Bonifačić D, Aralica M, Sotošek Tokmadžić V, Rački V, Tuškan Mohar L, Kučić N. Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients. Biomarkers [Internet]. 2017 June 29 [cited 2024 April 17];22(8):790-797. doi: 10.1080/1354750X.2017.1351001

D. Bonifačić, M. Aralica, V. Sotošek Tokmadžić, V. Rački, L. Tuškan Mohar and N. Kučić, "Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients", Biomarkers, vol. 22, no. 8, pp. 790-797, June 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:959430. [Accessed: 17 April 2024]

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Title (english)Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients
AuthorDavid Bonifačić
AuthorMerica Aralica
AuthorVlatka Sotošek Tokmadžić
AuthorValentino Rački
AuthorLidija Tuškan-Mohar
AuthorNatalia Kučić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
Background: Suitable biomarkers that have prognostic values are one of the key points of interest in ischaemic stroke. Increased sympathetic nervous system activity in ischaemic stroke causes multiple local and systemic effects that can be detrimental to the outcome. The mechanism of action is increased secretion and activity of catecholamines, whose end metabolic products are vanillylmandelic acid and homovanilic acid. Aim of our study was to determine whether these compounds can be used as potential prognostic biomarkers in ischaemic stroke, as a unique insight into the activity of the sympathetic nervous system. Methods: Urine samples of 96 patients with ischaemic stroke and transitory ischaemic attacks were analysed. Values of vanillylmandelic and homovanillic acids in urine were tested using liquid chromatography on the first and third day post-stroke. Severity of stroke was determined using the NIHSS scale, while functional outcome was determined using the Modified Rankin Scale. Results: Values of vanillylmandelic and homovanillic acids positively correlated with functional outcome of ischaemic stroke. Favorable outcomes correlated with decreased values, on contrary to increased values, which were associated with unfavourable outcomes. Conclusion: Determining the values of these compounds in the urine is an easily available prognostic tool for the ischaemic stroke outcome, while also influencing potential therapeutic changes
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBiomarkers
Numberingvol. 22, no. 8, pp. 790-797
p-ISSN1354-750X
e-ISSN1366-5804
DOIhttps://doi.org/10.1080/1354750X.2017.1351001
URN:NBNurn:nbn:hr:184:959430
Publication2017-06-29
Document URLhttps://doi.org/10.1080/1354750X.2017.1351001
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2017-11-21 18:50:35