prikaz prve stranice dokumenta The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage
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Scientific paper - Original scientific paper
The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage
Molecular and Cellular Proteomics, (2017); https://doi.org/10.1074/mcp.RA117.000160
Fabrik, Ivo; ...; ...; ...; ...; ...; ...; ...; ...; ...; Šantić, Marina; ...

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Fabrik, I. & Šantić, M. (2017). The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage. Molecular and Cellular Proteomics. doi: 10.1074/mcp.RA117.000160

Fabrik, Ivo and Marina Šantić. "The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage." Molecular and Cellular Proteomics, 2017. https://doi.org/10.1074/mcp.RA117.000160

Fabrik, Ivo and Marina Šantić. "The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage." Molecular and Cellular Proteomics (2017). https://doi.org/10.1074/mcp.RA117.000160

Fabrik, I. and Šantić, M. (2017) 'The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage', Molecular and Cellular Proteomics. doi: 10.1074/mcp.RA117.000160

Fabrik I, Šantić M. The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage. Molecular and Cellular Proteomics [Internet]. 2017 October 18 [cited 2024 December 05]. doi: 10.1074/mcp.RA117.000160

I. Fabrik and M. Šantić, "The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage", Molecular and Cellular Proteomics, October 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:793379. [Accessed: 05 December 2024]

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Metadata
Title (english)The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage
AuthorIvo Fabrik
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AuthorMarina Šantić
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Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Dendritic cells (DCs) infected by Francisella tularensis are poorly activated and do not undergo classical maturation process. While reasons of such unresponsiveness are not fully understood, their impact on the priming of immunity is well appreciated. Previous attempts to explain the behavior of Francisella-infected DCs were hypothesis-driven and focused on events at later stages of infection. Here, we took an alternative unbiased approach by applying methods of global phosphoproteomics to analyze the dynamics of cell signaling in primary DCs during the first hour of infection by Francisella tularensis. Presented results show that the early response of DCs to Francisella occurs in phases and that ERK and p38 signaling modules induced at the later stage are differentially regulated by virulent and attenuated ΔdsbA strain. These findings imply that the temporal orchestration of host pro-inflammatory pathways represents the integral part of Francisella life-cycle inside hijacked DCs.
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusAccepted
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMolecular and Cellular Proteomics
p-ISSN1535-9476
e-ISSN1535-9484
DOIhttps://doi.org/10.1074/mcp.RA117.000160
URN:NBNurn:nbn:hr:184:793379
Publication2017-10-18
Document URLhttp://www.mcponline.org/content/early/2017/10/18/mcp.RA117.000160.long
Document URLhttps://www.ncbi.nlm.nih.gov/pubmed/29046388
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-10-23 21:02:18