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Scientific paper - Original scientific paper
Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker
Collegium antropologicum, 32 (2008), 3; 741-746. urn:nbn:hr:184:436234
Mustać, Elvira; Zamolo, Gordana; Petković, Marija; Đorđević, Gordana; Radić, Jelena; Grgurević, Emina; Batinac, Tanja

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Mustać, E., Zamolo, G., Petković, M., Đorđević, G., Radić, J., Grgurević, E. & Batinac, T. (2008). Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker. Collegium antropologicum, 32. (3), 741-746. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:436234

Mustać, Elvira, et al. "Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker." Collegium antropologicum, vol. 32, no. 3, 2008, pp. 741-746. https://urn.nsk.hr/urn:nbn:hr:184:436234

Mustać, Elvira, Gordana Zamolo, Marija Petković, Gordana Đorđević, Jelena Radić, Emina Grgurević and Tanja Batinac. "Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker." Collegium antropologicum 32, no. 3 (2008): 741-746. https://urn.nsk.hr/urn:nbn:hr:184:436234

Mustać, E., et al. (2008) 'Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker', Collegium antropologicum, 32(3), pp. 741-746. Available at: https://urn.nsk.hr/urn:nbn:hr:184:436234 (Accessed 13 November 2024)

Mustać E, Zamolo G, Petković M, Đorđević G, Radić J, Grgurević E, and sur.. Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker. Collegium antropologicum [Internet]. 2008 September 02 [cited 2024 November 13];32(3):741-746. Available at: https://urn.nsk.hr/urn:nbn:hr:184:436234

E. Mustać, et al., "Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker", Collegium antropologicum, vol. 32, no. 3, pp. 741-746, September 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:436234. [Accessed: 13 November 2024]

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Metadata
Title (english)Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker
AuthorElvira Mustać
AuthorGordana Zamolo
AuthorMarija Petković
AuthorGordana Đorđević
AuthorJelena Radić
AuthorEmina Grgurević
AuthorTanja Batinac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Oncology and Radiotherapy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
The aim of this study was to analyse breast carcinomas with discordant receptor status, probably hormonal dependent (estrogen receptor (ER) positive, progesterone receptor (PR) negative or ER-PR+ subgroup profile) infiltrating ductal breast carcinomas not otherwise specified (IDC NOS). Specimens from 90 IDC NOS were grouped into three categories according to hormonal status: dependent (D) (ER+PR+), probably dependent (PD) (ER+PR- or ER-PR+) and non-dependent (ND) (ER-PR-); they were evaluated considering some established prognostic parameters in breast carcinomas. Statistically significant difference was found between tumor receptor status distribution and menopausal status (p= 0.0235), age of the patients (p=0.000467), histological grade (p=0.000003), vascular invasion (p=0.006), HER-2 status (p=0.0039) and Ki-67 proliferation rate (p=0.000311). D tumors were found exclusively in post-menopausal patients (average age 68.9 years), most of which had intermediate (II) grade, without vascular invasion, with HER-2 status score predominantly 0 or 1+ and lower Ki-67 proliferation rate. PD tumors were found predominantly in younger post-menopausal patients (average age 57.5 years), with vascular invasion found in 23% of the cases. ND tumors mostly had higher histological grade, showed the highest percentage of the Ki-67 positive tumor cells and vascular invasion in 30% of the cases. We conclude that the patients with PD breast carcinomas were younger post-menopausal women with the tumors moderately differentiated, HER-2 score 0 or 1+ and with lower Ki-67 proliferation rate.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 32, no. 3, pp. 741-746
p-ISSN0350-6134
URN:NBNurn:nbn:hr:184:436234
Publication2008-09-02
Document URLhttp://hrcak.srce.hr/27056
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-09-17 19:11:05