Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis

Grubić Kezele, Tanja; Blagojević Zagorac, Gordana; Jakovac, Hrvoje; Domitrović, Robert; Milin, Čedomila; Radošević-Stašić, Biserka

doi:10.1155/2013/750406

prikaz prve stranice dokumenta Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis

Scientific paper - Original scientific paper

Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis

Clinical and Developmental Immunology, 213 (2013); 750406. https://doi.org/10.1155/2013/750406

Grubić Kezele, Tanja; Blagojević Zagorac, Gordana; Jakovac, Hrvoje; Domitrović, Robert; Milin, Čedomila; Radošević-Stašić, Biserka

Cite this document

APA 6th Edition

Grubić Kezele, T., Blagojević Zagorac, G., Jakovac, H., Domitrović, R., Milin, Č. & Radošević Stašić, B. (2013). Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis. Clinical and Developmental Immunology, 213.. doi: 10.1155/2013/750406

MLA 8th Edition

Grubić Kezele, Tanja, et al. "Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis." Clinical and Developmental Immunology, vol. 213, 2013. https://doi.org/10.1155/2013/750406

Chicago 17th Edition

Grubić Kezele, Tanja, Gordana Blagojević Zagorac, Hrvoje Jakovac, Robert Domitrović, Čedomila Milin and Biserka Radošević Stašić. "Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis." Clinical and Developmental Immunology 213 (2013). https://doi.org/10.1155/2013/750406

Harvard

Grubić Kezele, T., et al. (2013) 'Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis', Clinical and Developmental Immunology, 213. doi: 10.1155/2013/750406

Vancouver

Grubić Kezele T, Blagojević Zagorac G, Jakovac H, Domitrović R, Milin Č, Radošević Stašić B. Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis. Clinical and Developmental Immunology [Internet]. 2013 [cited 2024 November 19];213. doi: 10.1155/2013/750406

IEEE

T. Grubić Kezele, G. Blagojević Zagorac, H. Jakovac, R. Domitrović, Č. Milin and B. Radošević Stašić, "Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis", Clinical and Developmental Immunology, vol. 213, 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:075264. [Accessed: 19 November 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:184:075264

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Metadata

Title (english)	Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis
Author	Tanja Grubić Kezele
Author	Gordana Blagojević Zagorac
Author	Hrvoje Jakovac
Author	Robert Domitrović
Author	Čedomila Milin
Author	Biserka Radošević-Stašić
Author's institution	University of Rijeka Faculty of Medicine (Department of Chemistry and Biochemistry)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences Medical Biochemistry
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences Human Physiology
Abstract (english)	In a search of peripheral factors that could be responsible for the discrepancy in susceptibility to EAE in Albino Oxford (AO) and Dark Agouti (DA) rats, we estimated the expression of metallothioneins I/II (MT), heat shock protein-gp96, interleukin (IL)- 6, and transforming growth factor (TGF)-𝛽 in the livers of these animals. Rats were immunized with bovine brain homogenate (BBH) emulsified in complete Freund adjuvant (CFA) or only with CFA. Western blot and immunohistochemical analyses were done on day 12 after the immunization, as well as in intact rats.The data have shown that during the first attack of EAE only the EAE prone-DA rats markedly upregulated the hepatic MTs, gp96, IL-6, and TGF-𝛽. In contrast, AO rats had a significantly higher expression of MT I/II, IL-6, and TGF-𝛽 in intact liver (𝑃 < 0, 001), suggesting that the greater constitutive expression of these proteins contributed to the resistance of EAE. Besides, since previously we found that AO rats reacted on immunization by an early upregulation of TGF-𝛽 on several hepatic structures (vascular endothelium, Kupffer cells, and hepatocytes), the data suggest that the specific hepatic microenvironment might contribute also to the faster recovery of these rats from EAE.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review - international
Publication version	Published version
Journal title	Clinical and Developmental Immunology
Numbering	vol. 213, 750406
e-ISSN	1740-2530
DOI	https://doi.org/10.1155/2013/750406
URN:NBN	urn:nbn:hr:184:075264
Publication	2013
Document URL	es http://dx.doi.org/10.1155/2013/750406
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2017-09-13 15:32:37