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master's thesis
SEKUNDARNA PREVENCIJA MOŽDANOG UDARA
2015. urn:nbn:hr:184:918562
Knežević, Mirna
University of Rijeka
Faculty of Medicine
Department of Neurology

Cite this document

Knežević, M. (2015). SEKUNDARNA PREVENCIJA MOŽDANOG UDARA (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:918562

Knežević, Mirna. "SEKUNDARNA PREVENCIJA MOŽDANOG UDARA." Master's thesis, University of Rijeka, Faculty of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:184:918562

Knežević, Mirna. "SEKUNDARNA PREVENCIJA MOŽDANOG UDARA." Master's thesis, University of Rijeka, Faculty of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:184:918562

Knežević, M. (2015). 'SEKUNDARNA PREVENCIJA MOŽDANOG UDARA', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 13 December 2024, https://urn.nsk.hr/urn:nbn:hr:184:918562

Knežević M. SEKUNDARNA PREVENCIJA MOŽDANOG UDARA [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2015 [cited 2024 December 13] Available at: https://urn.nsk.hr/urn:nbn:hr:184:918562

M. Knežević, "SEKUNDARNA PREVENCIJA MOŽDANOG UDARA", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:184:918562

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Metadata
TitleSEKUNDARNA PREVENCIJA MOŽDANOG UDARA
AuthorMirna Knežević
MentorLidija Tuškan-Mohar (mentor)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Neurology)
Rijeka
Defense date and country2015, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract
Moždani udar jedan je od glavnih uzroka smrti i invaliditeta u svijetu koji sa sobom nosi brojne posljedice. Iako je došlo do napretka u dijagnostici i liječenju, danas je glavni pristup kod njega prevencija. Sekundarna prevencija primjenjuje se kod osoba koje su preboljele MU ili TIA-u s ciljem sprječavanja ponovnog recidiva. Među najznačajnije čimbenike rizika ubrajaju se hipertenzija, dislipidemija, fibrilacija atrija, karotidna stenoza i dijabetes. Prvi korak u prevenciji je promjena nezdravog načina života. To uključuje prestanak pušenja, promjenu prehrane i redukciju tjelesne težine te povećanje tjelesne aktivnosti. Ukoliko osoba ima prateću bolest koja je povezana s razvojem MU, uvodi se ciljanja terapija. Tako se kod liječenja hipertenzije prednost daje diureticima i kombinaciji diuretika sa ACE inhibitorima dok se liječenje dislipidemije provodi uvođenjem statina. Kod stenoze karotidne arterije optimalno liječenje postiže se primjenom antiagregacijske terapije, uvođenjem statina i strogom redukcijom čimbenika rizika. Ukoliko je prisutna značajna stenoza karotidne arterije, indicirana je karotidna TEA ili se provodi endovaskularni zahvat. Aspirin, klopidogrel, dipiridamol i tiklopidin spadaju u skupinu antiagregacijskih lijekova, svojim djelovanjem smanjuju učestalost vaskularnih incidenata i samog MU-a. Peroralna antikoagulantna terapija veoma je učinkovita u prevenciji kardioembolijskog MU-a koji je najčešće uzrokovan fibrilacijom atrija. Najbolji terapeutski učinak postiže se varfarinom. Ipak zbog njegove uske terapijske širine i nuspojava proizvedeni su novi oralni antikoagulansi.
Abstract (english)
A stroke is one of the major death and disability causes in the world and has many consequences. Even though there has been a lot of progress in diagnostics and treatment, the main approach today is prevention. Secondary prevention can be used in people who have already had a stroke or TIA in order to prevent its relapse. The most important risk factors are hypertension, dyslipidemia, atrial fibrillation, carotid stenosis and diabetes. The first prevention step is to change the way of life which includes diet changes, reduction of body weight, increasing physical activity and quitting smoking. A more targeted therapy is used in people who have an accompanying disease. Therefore, diuretics and combination of diuretics and ACE inhibitors are used in treating hypertension, while dyslipidemia is treated with statins. An optimal treatment in carotid artery stenosis includes antiplatelet therapy, statins and a strict reduction of risk factors. Placing a stent or a carotid thrombendarterectomy is indicated if there is a significant level of carotid artery stenosis. Aspirin, clopidogrel, dipyridamole and ticlopidine, as representatives of platelet antiaggregation group of medications, decrease the frequency of vascular incidents and the stroke itself. Peroral anticoagulant therapy is proven to be very effective in preventing a cardioembolic stroke which is primarily caused with atrial fibrillation. In those cases, the best therapeutical effect is achieved with warfarin. However, due to its narrow therapeutic range and its side effects new oral anticoagulant drugs have been manufactured.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:918562
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2016-02-11 12:31:21